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Female asthma and atopy - impact on fertility: a systematic review

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DOI

  1. Fertility Treatment Resulting in Live Births in Women with Asthma - Associated with Perennial Allergy?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Clinical features and disease course of primary angioedema patients in a tertiary care hospital

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Postpartum airway responsiveness and exacerbation of asthma during pregnancy - a pilot study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Incidence and risk factors for exacerbations of asthma during pregnancy

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Safety of bronchodilators and corticosteroids for asthma during pregnancy: what we know and what we need to do better

    Research output: Contribution to journalJournal articleResearchpeer-review

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Background and objective: Asthma is one of the most common chronic diseases among women of reproductive age, and previous studies have suggested a link between female asthma and infertility. The aim of the present review is to provide an update on current knowledge of the association between female asthma and/or atopy and a reduction in fertility, ie, number of offspring, time to pregnancy (TTP) and need for fertility treatment.

Methods: Systematic review performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-guidelines.

Results: A total of 14 studies fulfilled the predefined criteria for inclusion in the present review. Six studies investigated the association between female asthma and/or atopy and number of offspring, of which one reported a positive, two a negative, and three no association. Three studies addressed the association between asthma and TTP and found that TTP was significantly prolonged in asthmatic women compared to non-asthmatic women. Five studies investigated subfertility and the need for fertility treatments of which two studies found a higher prevalence of infertility among women prescribed anti-asthma medication. One study found no difference in the number of fertility treatments of asthmatic women compared to non-asthmatic women, whereas three studies reported that female asthma was associated with significantly more fertility treatment compared to non-asthmatic women.

Conclusion: Although the available evidence is conflicting, there is a clear trend toward an association between female asthma and a reduction in fertility, and by that a larger proportion requiring fertility treatment, even though female asthma might not negatively affect total number of offspring.

Original languageEnglish
JournalJournal of Asthma and Allergy
Volume12
Pages (from-to)205-211
Number of pages7
ISSN1178-6965
DOIs
Publication statusPublished - 24 Jul 2019

    Research areas

  • Asthma, Fertility, Fertility treatment, Offspring, Time to pregnancy

ID: 57848138