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FDG-PET/CT identified distant metastases and synchronous cancer in squamous cell carcinoma of the head and neck: the impact of smoking and P16-s

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@article{5624f8c4ebfb444784d0373f307dabcd,
title = "FDG-PET/CT identified distant metastases and synchronous cancer in squamous cell carcinoma of the head and neck: the impact of smoking and P16-s",
abstract = "PURPOSE: Whole-body FDG-PET-CT is widely used at diagnosis of squamous cell carcinoma of the head and neck (SCCHN) but may identify suspicious lesions outside the neck that require investigation. This study evaluated the impact of smoking and P16-status on the incidence of malignant disease outside the head and neck region in newly diagnosed patients with SCCHN.METHODS: All PET-positive foci outside the head-neck area were registered in 1069 patients planned for postoperative or curative intent radiotherapy with whole-body FDG-PET/CT from 2006 to 2012. All patient files were retrospectively investigated and clinical parameters, tobacco use, HPV (P16)-status and subsequent malignant disease registered.RESULTS: Malignancy outside the neck was diagnosed in 9% of smokers, 2% of never-smokers, and 5% of patients with P16-positive oropharyngeal squamous cell carcinoma (OPSCC). Clinically suspicious PET-positive foci outside the head-neck were malignant in 55% of smokers, 34% of never-smokers, and in 38% of P16-pos OPSCC. All but two patients with cancer occurring outside the head and neck region were smokers.CONCLUSION: Malignancy outside the neck at diagnosis was more frequent in smokers compared to non-smokers or P16-pos OPSCC. A high proportion of clinically suspicious PET-positive foci were non-malignant.",
keywords = "Fluorodeoxyglucose F18, Head and Neck Neoplasms/diagnostic imaging, Humans, Oropharyngeal Neoplasms, Papillomavirus Infections, Positron Emission Tomography Computed Tomography, Retrospective Studies, Smoking/adverse effects, Squamous Cell Carcinoma of Head and Neck/diagnostic imaging",
author = "Mogens Bernsdorf and Annika Loft and Berthelsen, {Anne Kiil} and Julie Kjems and Vogelius, {Ivan Richter} and {von Buchwald}, Christian and Kristensen, {Claus Andrup} and Gothelf, {Anita Birgitte} and Jeppe Friborg",
year = "2022",
month = jan,
doi = "10.1007/s00405-021-06890-7",
language = "English",
volume = "279",
pages = "521--526",
journal = "Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde",
issn = "0003-9195",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - FDG-PET/CT identified distant metastases and synchronous cancer in squamous cell carcinoma of the head and neck

T2 - the impact of smoking and P16-s

AU - Bernsdorf, Mogens

AU - Loft, Annika

AU - Berthelsen, Anne Kiil

AU - Kjems, Julie

AU - Vogelius, Ivan Richter

AU - von Buchwald, Christian

AU - Kristensen, Claus Andrup

AU - Gothelf, Anita Birgitte

AU - Friborg, Jeppe

PY - 2022/1

Y1 - 2022/1

N2 - PURPOSE: Whole-body FDG-PET-CT is widely used at diagnosis of squamous cell carcinoma of the head and neck (SCCHN) but may identify suspicious lesions outside the neck that require investigation. This study evaluated the impact of smoking and P16-status on the incidence of malignant disease outside the head and neck region in newly diagnosed patients with SCCHN.METHODS: All PET-positive foci outside the head-neck area were registered in 1069 patients planned for postoperative or curative intent radiotherapy with whole-body FDG-PET/CT from 2006 to 2012. All patient files were retrospectively investigated and clinical parameters, tobacco use, HPV (P16)-status and subsequent malignant disease registered.RESULTS: Malignancy outside the neck was diagnosed in 9% of smokers, 2% of never-smokers, and 5% of patients with P16-positive oropharyngeal squamous cell carcinoma (OPSCC). Clinically suspicious PET-positive foci outside the head-neck were malignant in 55% of smokers, 34% of never-smokers, and in 38% of P16-pos OPSCC. All but two patients with cancer occurring outside the head and neck region were smokers.CONCLUSION: Malignancy outside the neck at diagnosis was more frequent in smokers compared to non-smokers or P16-pos OPSCC. A high proportion of clinically suspicious PET-positive foci were non-malignant.

AB - PURPOSE: Whole-body FDG-PET-CT is widely used at diagnosis of squamous cell carcinoma of the head and neck (SCCHN) but may identify suspicious lesions outside the neck that require investigation. This study evaluated the impact of smoking and P16-status on the incidence of malignant disease outside the head and neck region in newly diagnosed patients with SCCHN.METHODS: All PET-positive foci outside the head-neck area were registered in 1069 patients planned for postoperative or curative intent radiotherapy with whole-body FDG-PET/CT from 2006 to 2012. All patient files were retrospectively investigated and clinical parameters, tobacco use, HPV (P16)-status and subsequent malignant disease registered.RESULTS: Malignancy outside the neck was diagnosed in 9% of smokers, 2% of never-smokers, and 5% of patients with P16-positive oropharyngeal squamous cell carcinoma (OPSCC). Clinically suspicious PET-positive foci outside the head-neck were malignant in 55% of smokers, 34% of never-smokers, and in 38% of P16-pos OPSCC. All but two patients with cancer occurring outside the head and neck region were smokers.CONCLUSION: Malignancy outside the neck at diagnosis was more frequent in smokers compared to non-smokers or P16-pos OPSCC. A high proportion of clinically suspicious PET-positive foci were non-malignant.

KW - Fluorodeoxyglucose F18

KW - Head and Neck Neoplasms/diagnostic imaging

KW - Humans

KW - Oropharyngeal Neoplasms

KW - Papillomavirus Infections

KW - Positron Emission Tomography Computed Tomography

KW - Retrospective Studies

KW - Smoking/adverse effects

KW - Squamous Cell Carcinoma of Head and Neck/diagnostic imaging

UR - http://www.scopus.com/inward/record.url?scp=85107378293&partnerID=8YFLogxK

U2 - 10.1007/s00405-021-06890-7

DO - 10.1007/s00405-021-06890-7

M3 - Journal article

C2 - 34075488

VL - 279

SP - 521

EP - 526

JO - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde

JF - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde

SN - 0003-9195

IS - 1

ER -

ID: 66309771