Familial Atrial Fibrillation Predicts Increased Risk of Mortality: A Study in Danish Twins

Ingrid Elisabeth Christophersen; Esben Budtz-Jørgensen; Morten S Olesen; Stig Haunsø; Kaare Christensen; Jesper Hastrup Svendsen

doi:10.1161/CIRCEP.112.971580

Familial Atrial Fibrillation Predicts Increased Risk of Mortality: A Study in Danish Twins

Ingrid Elisabeth Christophersen, Esben Budtz-Jørgensen, Morten S Olesen, Stig Haunsø, Kaare Christensen, Jesper Hastrup Svendsen

16 Citations (Scopus)

Abstract

BACKGROUND: -Atrial fibrillation (AF) is a common arrhythmia. Several studies have shown association of genetic variants with AF, and that familial AF increases the risk of AF. We have previously shown a substantial heritability of AF in a twin study. The objective of this study was to determine whether having a co-twin with AF influences mortality. METHODS AND RESULTS: -We identified all Danish twins with AF born ≥ 1912 in the Danish Twin Registry, the National Patient Registry and the Central Office of Civil Registration. For each twin we randomly identified 4 twins without AF, matched on sex, zygosity and age. We compared survival among the co-twins of the affected twins (co-cases, n=2164) and the co-twins of the unaffected twins (co-controls, n=8626). The co-cases showed increased death rates compared to the co-controls (HR 1.20, 95% CI: 1.11-1.30, p

Original language	English
Journal	Circulation. Arrhythmia and Electrophysiology
Volume	6
Issue number	1
Pages (from-to)	10-5
ISSN	1941-3149
DOIs	https://doi.org/10.1161/CIRCEP.112.971580
Publication status	Published - 2013

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title = "Familial Atrial Fibrillation Predicts Increased Risk of Mortality: A Study in Danish Twins",

abstract = "BACKGROUND: -Atrial fibrillation (AF) is a common arrhythmia. Several studies have shown association of genetic variants with AF, and that familial AF increases the risk of AF. We have previously shown a substantial heritability of AF in a twin study. The objective of this study was to determine whether having a co-twin with AF influences mortality. METHODS AND RESULTS: -We identified all Danish twins with AF born ≥ 1912 in the Danish Twin Registry, the National Patient Registry and the Central Office of Civil Registration. For each twin we randomly identified 4 twins without AF, matched on sex, zygosity and age. We compared survival among the co-twins of the affected twins (co-cases, n=2164) and the co-twins of the unaffected twins (co-controls, n=8626). The co-cases showed increased death rates compared to the co-controls (HR 1.20, 95\% CI: 1.11-1.30, p",

author = "Christophersen, \{Ingrid Elisabeth\} and Esben Budtz-J{\o}rgensen and Olesen, \{Morten S\} and Stig Hauns{\o} and Kaare Christensen and Svendsen, \{Jesper Hastrup\}",

year = "2013",

doi = "10.1161/CIRCEP.112.971580",

language = "English",

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T1 - Familial Atrial Fibrillation Predicts Increased Risk of Mortality

T2 - A Study in Danish Twins

AU - Christophersen, Ingrid Elisabeth

AU - Budtz-Jørgensen, Esben

AU - Olesen, Morten S

AU - Haunsø, Stig

AU - Christensen, Kaare

AU - Svendsen, Jesper Hastrup

PY - 2013

Y1 - 2013

N2 - BACKGROUND: -Atrial fibrillation (AF) is a common arrhythmia. Several studies have shown association of genetic variants with AF, and that familial AF increases the risk of AF. We have previously shown a substantial heritability of AF in a twin study. The objective of this study was to determine whether having a co-twin with AF influences mortality. METHODS AND RESULTS: -We identified all Danish twins with AF born ≥ 1912 in the Danish Twin Registry, the National Patient Registry and the Central Office of Civil Registration. For each twin we randomly identified 4 twins without AF, matched on sex, zygosity and age. We compared survival among the co-twins of the affected twins (co-cases, n=2164) and the co-twins of the unaffected twins (co-controls, n=8626). The co-cases showed increased death rates compared to the co-controls (HR 1.20, 95% CI: 1.11-1.30, p

AB - BACKGROUND: -Atrial fibrillation (AF) is a common arrhythmia. Several studies have shown association of genetic variants with AF, and that familial AF increases the risk of AF. We have previously shown a substantial heritability of AF in a twin study. The objective of this study was to determine whether having a co-twin with AF influences mortality. METHODS AND RESULTS: -We identified all Danish twins with AF born ≥ 1912 in the Danish Twin Registry, the National Patient Registry and the Central Office of Civil Registration. For each twin we randomly identified 4 twins without AF, matched on sex, zygosity and age. We compared survival among the co-twins of the affected twins (co-cases, n=2164) and the co-twins of the unaffected twins (co-controls, n=8626). The co-cases showed increased death rates compared to the co-controls (HR 1.20, 95% CI: 1.11-1.30, p

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DO - 10.1161/CIRCEP.112.971580

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JO - Circulation. Arrhythmia and Electrophysiology

JF - Circulation. Arrhythmia and Electrophysiology

IS - 1

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Familial Atrial Fibrillation Predicts Increased Risk of Mortality: A Study in Danish Twins

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