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The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Factors influencing the prognosis for occupational hand eczema - new trends

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BACKGROUND: Variables traditionally reported to influence the prognosis of occupational hand eczema (OHE) comprise atopic dermatitis and contact sensitization. However, recent studies indicate that lifestyle factors may be of major importance.

OBJECTIVES: To identify factors influencing the prognosis in a cohort of patients with recognized OHE.

METHODS: In this register-based cohort study, individuals with hand eczema recognized as occupational disease in the period January 2010 to December 2011 were identified using files from the Labor Market Insurance Denmark and included in the study. At baseline information on gender, age, occupation, wet work, atopic dermatitis and contact sensitization was collected. In 2015 participants received a questionnaire with questions about lifestyle factors, current occupation, and healing of OHE.

RESULTS: 2703 patients received the questionnaire, and 1491 responded to the question regarding healing of OHE and were included in the study. In total 19.3% of patients reported complete healing at follow-up. Current tobacco smoking and a high level of stress were factors inversely associated with healing of hand eczema (P<0.001 and P=0.030, respectively), while a high level of exercise was significantly related to healing of eczema (P=0.011). Change of profession was a favorable prognostic factor, while age, gender, atopic dermatitis, contact sensitization and education did not significantly influence the prognosis.

CONCLUSIONS: Traditionally important risk factors such as atopic dermatitis and contact sensitization had no marked influence on prognosis, while lifestyle factors were of major importance. Our findings indicate that risk factors may vary over time, and this allows for new perspectives on prevention. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalBritish Journal of Dermatology
ISSN0007-0963
DOIs
Publication statusE-pub ahead of print - 9 Mar 2019

ID: 56914400