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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Facial Asymmetry in Children with Unicoronal Synostosis Who Have Undergone Craniofacial Reconstruction in Infancy

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DOI

  1. Spatially Detailed 3D Quantification of Improved Facial Symmetry After Surgery in Children With Unicoronal Synostosis

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  3. Histological investigation of the palatine bone in prenatal trisomy 21.

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  1. Phenotypic presentations of Hajdu-Cheney syndrome according to age - 5 distinct clinical presentations

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  2. Phenotypic variability in Muenke syndrome-observations from five Danish families

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  3. Multiple Fractures and Impaired Bone Fracture Healing in a Patient with Pycnodysostosis and Hypophosphatasia

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  4. Dynamic soft tissue changes in the orbit after a blowout fracture

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  5. Early Postoperative 18F-FET PET/MRI for Pediatric Brain and Spinal Cord Tumors

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OBJECTIVE:   Quantitatively assess 3D spatially detailed soft-tissue facial asymmetry in children who had undergone craniofacial reconstruction for Unicoronal Synostosis (UCS), and compare the facial asymmetry to control patients. It was hypothesized that there would be no significant differences in the facial asymmetry between the groups.

DESIGN:   Clinical, retrospective follow-up study. Methodological study Setting :  Primary care center.

PATIENTS/PARTICIPANTS:   Twenty-two children with UCS were selected after review of records.

INCLUSION CRITERIA: isolated UCS; surgically treated for UCS within the first 19 months of life, without secondary reconstruction; and DNA analysis for the Muenke mutation. An age- and sex-matched control group was employed.

INTERVENTIONS:   The UCS group had undergone bilateral craniotomy of the frontal bone with unilateral supraorbital rim advancement.

MAIN OUTCOME MEASURE(S):   Using 3D surface scanning, a detailed map of 3D asymmetry presenting the amount of asymmetry in the sagittal, vertical, and transverse directions was calculated for six facial subregions.

RESULTS:   The facial asymmetry in the UCS group was significantly larger than in the control group for all regions, to the largest extent in the sagittal direction (level of significance: 5%). The regions with the most pronounced asymmetry were cheeks (mean: 5.45 mm; SD: 1.83 mm), forehead (mean: 5.00 mm; SD: 1.57 mm), and eyes (mean: 4.26 mm; SD: 1.44 mm).

CONCLUSIONS:   Ninety percent of the UCS patients in the study had significant facial asymmetry throughout the facial area. The study demonstrates a methodology of facial asymmetry quantification well suited for soft-tissue surgical outcome evaluations and long-term follow-up studies in patients with craniofacial anomalies.

Original languageEnglish
JournalCleft Palate - Craniofacial Journal
Volume53
Issue number4
Pages (from-to)385-93
ISSN1055-6656
DOIs
Publication statusPublished - 2016

ID: 45845604