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Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes

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  • Simone de Jong
  • Kristel R van Eijk
  • Dave W L H Zeegers
  • Eric Strengman
  • Esther Janson
  • Jan H Veldink
  • Leonard H van den Berg
  • Wiepke Cahn
  • René S Kahn
  • Marco P M Boks
  • Roel A Ophoff
  • PGC Schizophrenia (GWAS) Consortium
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There is genetic evidence that schizophrenia is a polygenic disorder with a large number of loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of schizophrenia have had limited success, with the best finding at the MHC locus at chromosome 6p. A recent effort of the Psychiatric GWAS consortium (PGC) yielded five novel loci for schizophrenia. In this study, we aim to highlight additional schizophrenia susceptibility loci from the PGC study by combining the top association findings from the discovery stage (9394 schizophrenia cases and 12 462 controls) with expression QTLs (eQTLs) and differential gene expression in whole blood of schizophrenia patients and controls. We examined the 6192 single-nucleotide polymorphisms (SNPs) with significance threshold at P
Original languageEnglish
JournalEuropean Journal of Human Genetics
Volume20
Issue number9
Pages (from-to)1004-8
Number of pages5
ISSN1018-4813
DOIs
Publication statusPublished - 2012

    Research areas

  • Adult, Case-Control Studies, DNA-Binding Proteins, Female, Gene Expression, Genetic Predisposition to Disease, Genome-Wide Association Study, HLA-DRB3 Chains, Humans, Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Quantitative Trait, Heritable, Schizophrenia, Ubiquitin-Protein Ligases

ID: 36911373