Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes

Simone de Jong; Kristel R van Eijk; Dave W L H Zeegers; Eric Strengman; Esther Janson; Jan H Veldink; Leonard H van den Berg; Wiepke Cahn; René S Kahn; Marco P M Boks; Roel A Ophoff; PGC Schizophrenia (GWAS) Consortium

doi:10.1038/ejhg.2012.38

Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes

Simone de Jong, Kristel R van Eijk, Dave W L H Zeegers, Eric Strengman, Esther Janson, Jan H Veldink, Leonard H van den Berg, Wiepke Cahn, René S Kahn, Marco P M Boks, Roel A Ophoff, PGC Schizophrenia (GWAS) Consortium

57 Citations (Scopus)

Abstract

There is genetic evidence that schizophrenia is a polygenic disorder with a large number of loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of schizophrenia have had limited success, with the best finding at the MHC locus at chromosome 6p. A recent effort of the Psychiatric GWAS consortium (PGC) yielded five novel loci for schizophrenia. In this study, we aim to highlight additional schizophrenia susceptibility loci from the PGC study by combining the top association findings from the discovery stage (9394 schizophrenia cases and 12 462 controls) with expression QTLs (eQTLs) and differential gene expression in whole blood of schizophrenia patients and controls. We examined the 6192 single-nucleotide polymorphisms (SNPs) with significance threshold at P

Original language	English
Journal	European Journal of Human Genetics
Volume	20
Issue number	9
Pages (from-to)	1004-8
Number of pages	5
ISSN	1018-4813
DOIs	https://doi.org/10.1038/ejhg.2012.38
Publication status	Published - 2012

Keywords

Adult
Case-Control Studies
DNA-Binding Proteins
Female
Gene Expression
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA-DRB3 Chains
Humans
Male
Meta-Analysis as Topic
Middle Aged
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Quantitative Trait, Heritable
Schizophrenia
Ubiquitin-Protein Ligases

Access to Document

10.1038/ejhg.2012.38

Cite this

de Jong, S., van Eijk, K. R., Zeegers, D. W. L. H., Strengman, E., Janson, E., Veldink, J. H., van den Berg, L. H., Cahn, W., Kahn, R. S., Boks, M. P. M., Ophoff, R. A., & PGC Schizophrenia (GWAS) Consortium (2012). Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes. European Journal of Human Genetics, 20(9), 1004-8. https://doi.org/10.1038/ejhg.2012.38

de Jong, S, van Eijk, KR, Zeegers, DWLH, Strengman, E, Janson, E, Veldink, JH, van den Berg, LH, Cahn, W, Kahn, RS, Boks, MPM, Ophoff, RA & PGC Schizophrenia (GWAS) Consortium 2012, 'Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes', European Journal of Human Genetics, vol. 20, no. 9, pp. 1004-8. https://doi.org/10.1038/ejhg.2012.38

@article{2af592f8f8a34c77b0a66381d30d1cf8,

title = "Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes",

abstract = "There is genetic evidence that schizophrenia is a polygenic disorder with a large number of loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of schizophrenia have had limited success, with the best finding at the MHC locus at chromosome 6p. A recent effort of the Psychiatric GWAS consortium (PGC) yielded five novel loci for schizophrenia. In this study, we aim to highlight additional schizophrenia susceptibility loci from the PGC study by combining the top association findings from the discovery stage (9394 schizophrenia cases and 12 462 controls) with expression QTLs (eQTLs) and differential gene expression in whole blood of schizophrenia patients and controls. We examined the 6192 single-nucleotide polymorphisms (SNPs) with significance threshold at P",

keywords = "Adult, Case-Control Studies, DNA-Binding Proteins, Female, Gene Expression, Genetic Predisposition to Disease, Genome-Wide Association Study, HLA-DRB3 Chains, Humans, Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Quantitative Trait, Heritable, Schizophrenia, Ubiquitin-Protein Ligases",

author = "\{de Jong\}, Simone and \{van Eijk\}, \{Kristel R\} and Zeegers, \{Dave W L H\} and Eric Strengman and Esther Janson and Veldink, \{Jan H\} and \{van den Berg\}, \{Leonard H\} and Wiepke Cahn and Kahn, \{Ren{\'e} S\} and Boks, \{Marco P M\} and Ophoff, \{Roel A\} and \{PGC Schizophrenia (GWAS) Consortium\} and Werge, \{Thomas Mears\} and Thomas Hansen and Andr{\'e}s Ingason and Line Olsen and Thygesen, \{Johan Hilge\}",

year = "2012",

doi = "10.1038/ejhg.2012.38",

language = "English",

volume = "20",

pages = "1004--8",

journal = "European Journal of Human Genetics",

issn = "1018-4813",

publisher = "Springer Nature",

number = "9",

}

TY - JOUR

T1 - Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes

AU - de Jong, Simone

AU - van Eijk, Kristel R

AU - Zeegers, Dave W L H

AU - Strengman, Eric

AU - Janson, Esther

AU - Veldink, Jan H

AU - van den Berg, Leonard H

AU - Cahn, Wiepke

AU - Kahn, René S

AU - Boks, Marco P M

AU - Ophoff, Roel A

AU - PGC Schizophrenia (GWAS) Consortium

AU - Werge, Thomas Mears

AU - Hansen, Thomas

AU - Ingason, Andrés

AU - Olsen, Line

AU - Thygesen, Johan Hilge

PY - 2012

Y1 - 2012

N2 - There is genetic evidence that schizophrenia is a polygenic disorder with a large number of loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of schizophrenia have had limited success, with the best finding at the MHC locus at chromosome 6p. A recent effort of the Psychiatric GWAS consortium (PGC) yielded five novel loci for schizophrenia. In this study, we aim to highlight additional schizophrenia susceptibility loci from the PGC study by combining the top association findings from the discovery stage (9394 schizophrenia cases and 12 462 controls) with expression QTLs (eQTLs) and differential gene expression in whole blood of schizophrenia patients and controls. We examined the 6192 single-nucleotide polymorphisms (SNPs) with significance threshold at P

AB - There is genetic evidence that schizophrenia is a polygenic disorder with a large number of loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of schizophrenia have had limited success, with the best finding at the MHC locus at chromosome 6p. A recent effort of the Psychiatric GWAS consortium (PGC) yielded five novel loci for schizophrenia. In this study, we aim to highlight additional schizophrenia susceptibility loci from the PGC study by combining the top association findings from the discovery stage (9394 schizophrenia cases and 12 462 controls) with expression QTLs (eQTLs) and differential gene expression in whole blood of schizophrenia patients and controls. We examined the 6192 single-nucleotide polymorphisms (SNPs) with significance threshold at P

KW - Adult

KW - Case-Control Studies

KW - DNA-Binding Proteins

KW - Female

KW - Gene Expression

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - HLA-DRB3 Chains

KW - Humans

KW - Male

KW - Meta-Analysis as Topic

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

KW - Quantitative Trait, Heritable

KW - Schizophrenia

KW - Ubiquitin-Protein Ligases

UR - https://www.scopus.com/pages/publications/84865268482

U2 - 10.1038/ejhg.2012.38

DO - 10.1038/ejhg.2012.38

M3 - Journal article

C2 - 22433715

SN - 1018-4813

VL - 20

SP - 1004

EP - 1008

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

IS - 9

ER -

Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this