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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Expression Patterns of Biomarkers in Primary Tumors and Corresponding Metastases in Breast Cancer

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  1. Ovarian Clear Cell Carcinoma: From Morphology to Molecular Biology

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  2. Archival bone marrow samples: suitable for multiple biomarker analysis

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  3. Differential Expression of miR-155 and miR-21 in Tumor and Stroma Cells in Diffuse Large B-Cell Lymphoma

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  1. Joint tobacco smoking and alcohol intake exacerbates cancer risk in women- the Danish nurse cohort

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  2. Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma

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  3. PD-L1 expression is low in large B-cell lymphoma with MYC or double-hit translocation

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Tumor heterogeneity has been shown for several cancers including breast cancer (BC). Despite the fact that expression of tumor markers may change throughout the metastatic process, rebiopsies at the time of recurrence are still not performed routinely at all institutions. The aims of the study were to evaluate changes in biomarker profiles during the metastatic process and to investigate whether previous anthracycline or endocrine therapy given in the adjuvant setting could affect the biomarker profile in metastatic lesions. We investigated the expression pattern of ER, HER2, TOP2a, TOP1, p53, Bcl-2, and Ki-67 in 110 paired samples of primary BC and corresponding asynchronous metastases. We found discordant expressions in primary tumor and metastasis for all biomarkers, although only significant for Ki-67. Changes in the expression profile of the metastatic lesions would have altered treatment decisions in 14% of patients. We found no effect of previous anthracycline or endocrine therapy on the expression profiles. Our data confirm that discordant expressions of biomarkers are common in BC and often carry therapeutic consequences. This emphasizes the need for biopsies from metastatic lesions, even in cases where the localization of the metastatic process is not easily accessible.

Original languageEnglish
JournalApplied Immunohistochemistry and Molecular Morphology
Volume26
Issue number1
ISSN1541-2016
DOIs
Publication statusPublished - 2018

ID: 49784872