Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

Michael F Ofori; Trine Staalsoe; Victoria Bam; Maja Lundquist; Kim P David; Edmund N L Browne; Bartholomew D Akanmori; Lars Hviid

doi:10.1128/IAI.71.3.1584-1586.2003

Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

Michael F Ofori, Trine Staalsoe, Victoria Bam, Maja Lundquist, Kim P David, Edmund N L Browne, Bartholomew D Akanmori, Lars Hviid

33 Citations (Scopus)

Abstract

Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA(PAM)) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research.

Original language	English
Journal	Infection and Immunity
Volume	71
Issue number	3
Pages (from-to)	1584-6
Number of pages	3
ISSN	0019-9567
DOIs	https://doi.org/10.1128/IAI.71.3.1584-1586.2003
Publication status	Published - Mar 2003
Externally published	Yes

Keywords

Animals
Antibodies, Protozoan/blood
Antigens, Protozoan/blood
Antigens, Surface/blood
Female
Humans
Immunoglobulin G/blood
Malaria, Falciparum/immunology
Placenta/parasitology
Plasmodium falciparum/immunology
Pregnancy
Pregnancy Complications, Parasitic/immunology

Access to Document

10.1128/IAI.71.3.1584-1586.2003

Cite this

Ofori, M. F., Staalsoe, T., Bam, V., Lundquist, M., David, K. P., Browne, E. N. L., Akanmori, B. D., & Hviid, L. (2003). Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection. Infection and Immunity, 71(3), 1584-6. https://doi.org/10.1128/IAI.71.3.1584-1586.2003

Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection. / Ofori, Michael F; Staalsoe, Trine; Bam, Victoria et al.
In: Infection and Immunity, Vol. 71, No. 3, 03.2003, p. 1584-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Ofori, MF, Staalsoe, T, Bam, V, Lundquist, M, David, KP, Browne, ENL, Akanmori, BD & Hviid, L 2003, 'Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection', Infection and Immunity, vol. 71, no. 3, pp. 1584-6. https://doi.org/10.1128/IAI.71.3.1584-1586.2003

@article{febe8632ba774fe5811d9d89907280b7,

title = "Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection",

abstract = "Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA(PAM)) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research.",

keywords = "Animals, Antibodies, Protozoan/blood, Antigens, Protozoan/blood, Antigens, Surface/blood, Female, Humans, Immunoglobulin G/blood, Malaria, Falciparum/immunology, Placenta/parasitology, Plasmodium falciparum/immunology, Pregnancy, Pregnancy Complications, Parasitic/immunology",

author = "Ofori, {Michael F} and Trine Staalsoe and Victoria Bam and Maja Lundquist and David, {Kim P} and Browne, {Edmund N L} and Akanmori, {Bartholomew D} and Lars Hviid",

year = "2003",

month = mar,

doi = "10.1128/IAI.71.3.1584-1586.2003",

language = "English",

volume = "71",

pages = "1584--6",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "3",

}

TY - JOUR

T1 - Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

AU - Ofori, Michael F

AU - Staalsoe, Trine

AU - Bam, Victoria

AU - Lundquist, Maja

AU - David, Kim P

AU - Browne, Edmund N L

AU - Akanmori, Bartholomew D

AU - Hviid, Lars

PY - 2003/3

Y1 - 2003/3

N2 - Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA(PAM)) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research.

AB - Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA(PAM)) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research.

KW - Animals

KW - Antibodies, Protozoan/blood

KW - Antigens, Protozoan/blood

KW - Antigens, Surface/blood

KW - Female

KW - Humans

KW - Immunoglobulin G/blood

KW - Malaria, Falciparum/immunology

KW - Placenta/parasitology

KW - Plasmodium falciparum/immunology

KW - Pregnancy

KW - Pregnancy Complications, Parasitic/immunology

U2 - 10.1128/IAI.71.3.1584-1586.2003

DO - 10.1128/IAI.71.3.1584-1586.2003

M3 - Journal article

C2 - 12595482

SN - 0019-9567

VL - 71

SP - 1584

EP - 1586

JO - Infection and Immunity

JF - Infection and Immunity

IS - 3

ER -

Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

Abstract

Keywords

Access to Document

Fingerprint

Cite this