Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer

Martin Blomberg Jensen; Claus B. Andersen; John E Nielsen; Per Bagi; Anne Jørgensen; Anders Juul; Henrik Leffers

doi:10.1016/j.jsbmb.2010.03.069

Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer

Martin Blomberg Jensen, Claus B. Andersen, John E Nielsen, Per Bagi, Anne Jørgensen, Anders Juul, Henrik Leffers

68 Citations (Scopus)

Abstract

The vitamin D receptor (VDR), CYP27B1 and CYP24A1 are expressed in the human kidney, but the segmental expression of the 25-hydroxylases is unknown. A comprehensive analysis of CYP2R1, CYP27A1, CYP27B1, VDR and CYP24A1 expression in normal kidney and renal clear cell cancer (CCc) would reveal the segmental location of expression, and clarify whether the reported loss of VDR in CCc is coincident with alterations of vitamin D metabolism.

Original language	English
Journal	The Journal of steroid biochemistry and molecular biology
Volume	121
Issue number	1-2
Pages (from-to)	376-82
Number of pages	7
DOIs	https://doi.org/10.1016/j.jsbmb.2010.03.069
Publication status	Published - 1 Jul 2010

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10.1016/j.jsbmb.2010.03.069

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Blomberg Jensen, M., Andersen, C. B., Nielsen, J. E., Bagi, P., Jørgensen, A., Juul, A., & Leffers, H. (2010). Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer. The Journal of steroid biochemistry and molecular biology, 121(1-2), 376-82. https://doi.org/10.1016/j.jsbmb.2010.03.069

Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer. / Blomberg Jensen, Martin; Andersen, Claus B.; Nielsen, John E et al.
In: The Journal of steroid biochemistry and molecular biology, Vol. 121, No. 1-2, 01.07.2010, p. 376-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Blomberg Jensen, M, Andersen, CB, Nielsen, JE, Bagi, P , Jørgensen, A , Juul, A & Leffers, H 2010, 'Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer', The Journal of steroid biochemistry and molecular biology, vol. 121, no. 1-2, pp. 376-82. https://doi.org/10.1016/j.jsbmb.2010.03.069

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abstract = "The vitamin D receptor (VDR), CYP27B1 and CYP24A1 are expressed in the human kidney, but the segmental expression of the 25-hydroxylases is unknown. A comprehensive analysis of CYP2R1, CYP27A1, CYP27B1, VDR and CYP24A1 expression in normal kidney and renal clear cell cancer (CCc) would reveal the segmental location of expression, and clarify whether the reported loss of VDR in CCc is coincident with alterations of vitamin D metabolism.",

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AU - Bagi, Per

AU - Jørgensen, Anne

AU - Juul, Anders

AU - Leffers, Henrik

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AB - The vitamin D receptor (VDR), CYP27B1 and CYP24A1 are expressed in the human kidney, but the segmental expression of the 25-hydroxylases is unknown. A comprehensive analysis of CYP2R1, CYP27A1, CYP27B1, VDR and CYP24A1 expression in normal kidney and renal clear cell cancer (CCc) would reveal the segmental location of expression, and clarify whether the reported loss of VDR in CCc is coincident with alterations of vitamin D metabolism.

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Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer

Abstract

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