Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin

Gwladys I Bertin; Thomas Lavstsen; François Guillonneau; Justin Doritchamou; Christian W Wang; Jakob S Jespersen; Sem Ezimegnon; Nadine Fievet; Maroufou J Alao; Francis Lalya; Achille Massougbodji; Nicaise Tuikue Ndam; Thor G Theander; Philippe Deloron

doi:10.1371/journal.pone.0068368

Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin

Gwladys I Bertin, Thomas Lavstsen, François Guillonneau, Justin Doritchamou, Christian W Wang, Jakob S Jespersen, Sem Ezimegnon, Nadine Fievet, Maroufou J Alao, Francis Lalya, Achille Massougbodji, Nicaise Tuikue Ndam, Thor G Theander, Philippe Deloron

58 Citations (Scopus)

Abstract

Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based on sequence homology PfEMP-1 variants have been grouped into three major groups A-C, the highly conserved VAR2CSA variants, and semi-conserved types defined by tandem runs of specific domains ("domain cassettes" (DC)). The PfEMP-1 type expressed determines the adherence phenotype, and is associated with clinical outcome of infection.

Original language	English
Journal	P L o S One
Volume	8
Issue number	7
Pages (from-to)	e68368
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0068368
Publication status	Published - 2013

Access to Document

10.1371/journal.pone.0068368

Cite this

Bertin, G. I., Lavstsen, T., Guillonneau, F., Doritchamou, J., Wang, C. W., Jespersen, J. S., Ezimegnon, S., Fievet, N., Alao, M. J., Lalya, F., Massougbodji, A., Ndam, N. T., Theander, T. G., & Deloron, P. (2013). Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin. P L o S One, 8(7), e68368. https://doi.org/10.1371/journal.pone.0068368

Bertin, GI, Lavstsen, T, Guillonneau, F, Doritchamou, J, Wang, CW, Jespersen, JS, Ezimegnon, S, Fievet, N, Alao, MJ, Lalya, F, Massougbodji, A, Ndam, NT, Theander, TG & Deloron, P 2013, 'Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin', P L o S One, vol. 8, no. 7, pp. e68368. https://doi.org/10.1371/journal.pone.0068368

@article{83983e5b65624d488320b1aa03bbfe2f,

title = "Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin",

abstract = "Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based on sequence homology PfEMP-1 variants have been grouped into three major groups A-C, the highly conserved VAR2CSA variants, and semi-conserved types defined by tandem runs of specific domains ({"}domain cassettes{"} (DC)). The PfEMP-1 type expressed determines the adherence phenotype, and is associated with clinical outcome of infection.",

author = "Bertin, \{Gwladys I\} and Thomas Lavstsen and Fran{\c c}ois Guillonneau and Justin Doritchamou and Wang, \{Christian W\} and Jespersen, \{Jakob S\} and Sem Ezimegnon and Nadine Fievet and Alao, \{Maroufou J\} and Francis Lalya and Achille Massougbodji and Ndam, \{Nicaise Tuikue\} and Theander, \{Thor G\} and Philippe Deloron",

year = "2013",

doi = "10.1371/journal.pone.0068368",

language = "English",

volume = "8",

pages = "e68368",

journal = "P L o S One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "7",

}

TY - JOUR

T1 - Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin

AU - Bertin, Gwladys I

AU - Lavstsen, Thomas

AU - Guillonneau, François

AU - Doritchamou, Justin

AU - Wang, Christian W

AU - Jespersen, Jakob S

AU - Ezimegnon, Sem

AU - Fievet, Nadine

AU - Alao, Maroufou J

AU - Lalya, Francis

AU - Massougbodji, Achille

AU - Ndam, Nicaise Tuikue

AU - Theander, Thor G

AU - Deloron, Philippe

PY - 2013

Y1 - 2013

N2 - Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based on sequence homology PfEMP-1 variants have been grouped into three major groups A-C, the highly conserved VAR2CSA variants, and semi-conserved types defined by tandem runs of specific domains ("domain cassettes" (DC)). The PfEMP-1 type expressed determines the adherence phenotype, and is associated with clinical outcome of infection.

AB - Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based on sequence homology PfEMP-1 variants have been grouped into three major groups A-C, the highly conserved VAR2CSA variants, and semi-conserved types defined by tandem runs of specific domains ("domain cassettes" (DC)). The PfEMP-1 type expressed determines the adherence phenotype, and is associated with clinical outcome of infection.

UR - https://www.scopus.com/pages/publications/84880830141

U2 - 10.1371/journal.pone.0068368

DO - 10.1371/journal.pone.0068368

M3 - Journal article

C2 - 23922654

SN - 1932-6203

VL - 8

SP - e68368

JO - P L o S One

JF - P L o S One

IS - 7

ER -

Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin

Abstract

Access to Document

Other files and links

Fingerprint

Cite this