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Expression of melanoma cell adhesion molecule-1 (MCAM-1) in natalizumab-treated multiple sclerosis

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  2. Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

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  4. Inflammatory markers of CHMP2B-mediated frontotemporal dementia

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  1. Exposure to passive smoking during adolescence is associated with an increased risk of developing multiple sclerosis

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  2. Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS

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  3. Biomarkers of inflammation and epithelial barrier function in multiple sclerosis

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  4. Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium

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  5. Multiplex assessment of cerebrospinal fluid biomarkers in multiple sclerosis

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The objectives were to study the expression of very late antigen (VLA)-4, melanoma cell adhesion molecule-1 (MCAM-1) and activated leukocyte cell adhesion molecule (ALCAM) on CD4+ T cells during natalizumab treatment and to investigate the association with disease activity. We find that subgroups of autoreactive T cells are retained in peripheral blood, in particular MOG-reactive CD4+ T cells expressing MCAM-1. The expression of MCAM-1 or ALCAM on CD4+ T cells was, however, not clearly associated with disease activity (clinical or MRI) during natalizumab treatment. We confirm upregulation of MCAM-1 on CD4+ T cells during natalizumab treatment while VLA-4 is downregulated.

Original languageEnglish
JournalJournal of Neuroimmunology
Volume337
Pages (from-to)577085
ISSN0165-5728
DOIs
Publication statusPublished - 15 Dec 2019

    Research areas

  • Adult, Aged, CD146 Antigen/biosynthesis, CD4-Positive T-Lymphocytes/drug effects, Cohort Studies, Female, Gene Expression, Humans, Immunologic Factors/administration & dosage, Infusions, Intravenous, Male, Middle Aged, Multiple Sclerosis/blood, Natalizumab/administration & dosage, Prospective Studies, Young Adult

ID: 61518900