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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV

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Fibroblast growth factor (FGF)-21 is a novel regulator of glucose and lipid metabolism. Recently, increased FGF-21 mRNA expression in muscle was found in patients with type 2 diabetes, but the role for FGF-21 in muscle is not well understood. Patients with HIV-infection and lipodystrophy are characterised by various degree of lipid-driven insulin resistance. We hypothesized that muscle FGF-21 mRNA would be altered in HIV patients with lipodystrophy.
Original languageEnglish
JournalP L o S One
Volume8
Issue number3
Pages (from-to)e55632
ISSN1932-6203
DOIs
Publication statusPublished - 2013

    Research areas

  • Adult, Case-Control Studies, Female, Fibroblast Growth Factors, HIV Infections, Humans, Insulin Resistance, Lipodystrophy, Male, Middle Aged, Muscle, Skeletal

ID: 40879085