Expression of 5-HT1B receptors in human nasal mucosa

R Uddman; J Longmore; L O Cardell; L Edvinsson

Expression of 5-HT1B receptors in human nasal mucosa

R Uddman, J Longmore, L O Cardell, L Edvinsson

5 Citations (Scopus)

Abstract

5-HT1B receptors were discovered in human nasal mucosa using immunocytochemistry. Strong immunoreaction was seen around small blood vessels mainly confined to the smooth muscle cell layer. In contrast, no immunoreaction for 5-HT1D was seen. The possibility of local release in connection with specific target receptors suggests a role for 5-HT in the regulation of vascular tone, glandular secretion and epithelial functions and that 5-HT1B receptor agonists may be of clinical importance.

Original language	English
Journal	Acta Oto-Laryngologica
Volume	121
Issue number	3
Pages (from-to)	403-6
Number of pages	4
ISSN	0001-6489
Publication status	Published - Apr 2001
Externally published	Yes

Keywords

Adult
Female
Humans
Male
Microcirculation
Muscle, Smooth, Vascular
Nasal Mucosa
Nasal Obstruction
Receptor, Serotonin, 5-HT1B
Receptor, Serotonin, 5-HT1D
Receptors, Serotonin
Trigeminal Ganglion

Cite this

@article{25c230e51cd74e37b2084da08ca79cde,

title = "Expression of 5-HT1B receptors in human nasal mucosa",

abstract = "5-HT1B receptors were discovered in human nasal mucosa using immunocytochemistry. Strong immunoreaction was seen around small blood vessels mainly confined to the smooth muscle cell layer. In contrast, no immunoreaction for 5-HT1D was seen. The possibility of local release in connection with specific target receptors suggests a role for 5-HT in the regulation of vascular tone, glandular secretion and epithelial functions and that 5-HT1B receptor agonists may be of clinical importance.",

keywords = "Adult, Female, Humans, Male, Microcirculation, Muscle, Smooth, Vascular, Nasal Mucosa, Nasal Obstruction, Receptor, Serotonin, 5-HT1B, Receptor, Serotonin, 5-HT1D, Receptors, Serotonin, Trigeminal Ganglion",

author = "R Uddman and J Longmore and Cardell, \{L O\} and L Edvinsson",

year = "2001",

month = apr,

language = "English",

volume = "121",

pages = "403--6",

journal = "Acta Oto-Laryngologica",

issn = "0001-6489",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - Expression of 5-HT1B receptors in human nasal mucosa

AU - Uddman, R

AU - Longmore, J

AU - Cardell, L O

AU - Edvinsson, L

PY - 2001/4

Y1 - 2001/4

N2 - 5-HT1B receptors were discovered in human nasal mucosa using immunocytochemistry. Strong immunoreaction was seen around small blood vessels mainly confined to the smooth muscle cell layer. In contrast, no immunoreaction for 5-HT1D was seen. The possibility of local release in connection with specific target receptors suggests a role for 5-HT in the regulation of vascular tone, glandular secretion and epithelial functions and that 5-HT1B receptor agonists may be of clinical importance.

AB - 5-HT1B receptors were discovered in human nasal mucosa using immunocytochemistry. Strong immunoreaction was seen around small blood vessels mainly confined to the smooth muscle cell layer. In contrast, no immunoreaction for 5-HT1D was seen. The possibility of local release in connection with specific target receptors suggests a role for 5-HT in the regulation of vascular tone, glandular secretion and epithelial functions and that 5-HT1B receptor agonists may be of clinical importance.

KW - Adult

KW - Female

KW - Humans

KW - Male

KW - Microcirculation

KW - Muscle, Smooth, Vascular

KW - Nasal Mucosa

KW - Nasal Obstruction

KW - Receptor, Serotonin, 5-HT1B

KW - Receptor, Serotonin, 5-HT1D

KW - Receptors, Serotonin

KW - Trigeminal Ganglion

UR - https://www.scopus.com/pages/publications/0035317625

M3 - Journal article

C2 - 11425209

SN - 0001-6489

VL - 121

SP - 403

EP - 406

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

IS - 3

ER -

Expression of 5-HT1B receptors in human nasal mucosa

Abstract

Keywords

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