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Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population

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@article{8fc63ff8e6bc4ecb90343bcfe0f995d2,
title = "Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population",
abstract = "BACKGROUND: Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10{\%} of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could have increased trans-epidermal penetration of other chemicals.OBJECTIVES: We investigated exposure to non-persistent chemicals in young Danish men with and without FLG mutations.METHODS: Concentrations of eight simple phenols, six parabens and nine UV filters were analysed in urine from 65 FLG loss-of-function mutation carriers and 130 non-carriers (controls). Regression analyses, controlling for urinary dilution and confounders, were performed to estimate associations between FLG mutation status and chemical concentrations in urine.RESULTS: FLG mutation carriers had 80{\%} (13-180{\%}) higher urinary concentrations of methyl paraben (MeP) and 91{\%} (13-219{\%}) higher concentrations of n-propyl paraben (n-PrP) than controls. For 13 compounds, levels were higher in FLG mutation carriers, although differences were only statistically significant for MeP and n-PrP. Combined statistical analysis of concentrations of all the 18 compounds that were detectable in >10{\%} of subjects, suggested that concentrations were generally higher in mutation carriers (p=0.03).CONCLUSION: FLG loss-of-function mutation carriers have a higher internal exposure to some non-persistent chemicals, independently of atopic dermatitis. This may be due to increased trans-epidermal absorption and/or higher exposure, and mutation carriers may constitute a group susceptible to increased absorption of chemicals and topical medication.",
keywords = "Journal Article",
author = "Joensen, {Ulla N} and Niels J{\o}rgensen and Thyssen, {Jacob P} and Petersen, {J{\o}rgen Holm} and Szecsi, {Pal B} and Steen Stender and Anna-Maria Andersson and Skakkeb{\ae}k, {Niels E} and Hanne Frederiksen",
note = "Copyright {\circledC} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
month = "8",
doi = "10.1016/j.envint.2017.05.013",
language = "English",
volume = "105",
pages = "105--111",
journal = "Environmental International",
issn = "0160-4120",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - Exposure to phenols, parabens and UV filters

T2 - Associations with loss-of-function mutations in the filaggrin gene in men from the general population

AU - Joensen, Ulla N

AU - Jørgensen, Niels

AU - Thyssen, Jacob P

AU - Petersen, Jørgen Holm

AU - Szecsi, Pal B

AU - Stender, Steen

AU - Andersson, Anna-Maria

AU - Skakkebæk, Niels E

AU - Frederiksen, Hanne

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/8

Y1 - 2017/8

N2 - BACKGROUND: Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10% of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could have increased trans-epidermal penetration of other chemicals.OBJECTIVES: We investigated exposure to non-persistent chemicals in young Danish men with and without FLG mutations.METHODS: Concentrations of eight simple phenols, six parabens and nine UV filters were analysed in urine from 65 FLG loss-of-function mutation carriers and 130 non-carriers (controls). Regression analyses, controlling for urinary dilution and confounders, were performed to estimate associations between FLG mutation status and chemical concentrations in urine.RESULTS: FLG mutation carriers had 80% (13-180%) higher urinary concentrations of methyl paraben (MeP) and 91% (13-219%) higher concentrations of n-propyl paraben (n-PrP) than controls. For 13 compounds, levels were higher in FLG mutation carriers, although differences were only statistically significant for MeP and n-PrP. Combined statistical analysis of concentrations of all the 18 compounds that were detectable in >10% of subjects, suggested that concentrations were generally higher in mutation carriers (p=0.03).CONCLUSION: FLG loss-of-function mutation carriers have a higher internal exposure to some non-persistent chemicals, independently of atopic dermatitis. This may be due to increased trans-epidermal absorption and/or higher exposure, and mutation carriers may constitute a group susceptible to increased absorption of chemicals and topical medication.

AB - BACKGROUND: Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10% of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could have increased trans-epidermal penetration of other chemicals.OBJECTIVES: We investigated exposure to non-persistent chemicals in young Danish men with and without FLG mutations.METHODS: Concentrations of eight simple phenols, six parabens and nine UV filters were analysed in urine from 65 FLG loss-of-function mutation carriers and 130 non-carriers (controls). Regression analyses, controlling for urinary dilution and confounders, were performed to estimate associations between FLG mutation status and chemical concentrations in urine.RESULTS: FLG mutation carriers had 80% (13-180%) higher urinary concentrations of methyl paraben (MeP) and 91% (13-219%) higher concentrations of n-propyl paraben (n-PrP) than controls. For 13 compounds, levels were higher in FLG mutation carriers, although differences were only statistically significant for MeP and n-PrP. Combined statistical analysis of concentrations of all the 18 compounds that were detectable in >10% of subjects, suggested that concentrations were generally higher in mutation carriers (p=0.03).CONCLUSION: FLG loss-of-function mutation carriers have a higher internal exposure to some non-persistent chemicals, independently of atopic dermatitis. This may be due to increased trans-epidermal absorption and/or higher exposure, and mutation carriers may constitute a group susceptible to increased absorption of chemicals and topical medication.

KW - Journal Article

U2 - 10.1016/j.envint.2017.05.013

DO - 10.1016/j.envint.2017.05.013

M3 - Journal article

VL - 105

SP - 105

EP - 111

JO - Environmental International

JF - Environmental International

SN - 0160-4120

ER -

ID: 51554537