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Exploring Comorbidity Within Mental Disorders Among a Danish National Population

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Harvard

Plana-Ripoll, O, Pedersen, CB, Holtz, Y, Benros, ME, Dalsgaard, S, de Jonge, P, Fan, CC, Degenhardt, L, Ganna, A, Greve, AN, Gunn, J, Iburg, KM, Kessing, LV, Lee, BK, Lim, CCW, Mors, O, Nordentoft, M, Prior, A, Roest, AM, Saha, S, Schork, A, Scott, JG, Scott, KM, Stedman, T, Sørensen, HJ, Werge, T, Whiteford, HA, Laursen, TM, Agerbo, E, Kessler, RC, Mortensen, PB & McGrath, JJ 2019, 'Exploring Comorbidity Within Mental Disorders Among a Danish National Population' JAMA Psychiatry. https://doi.org/10.1001/jamapsychiatry.2018.3658

APA

Plana-Ripoll, O., Pedersen, C. B., Holtz, Y., Benros, M. E., Dalsgaard, S., de Jonge, P., ... McGrath, J. J. (2019). Exploring Comorbidity Within Mental Disorders Among a Danish National Population. JAMA Psychiatry. https://doi.org/10.1001/jamapsychiatry.2018.3658

CBE

Plana-Ripoll O, Pedersen CB, Holtz Y, Benros ME, Dalsgaard S, de Jonge P, Fan CC, Degenhardt L, Ganna A, Greve AN, Gunn J, Iburg KM, Kessing LV, Lee BK, Lim CCW, Mors O, Nordentoft M, Prior A, Roest AM, Saha S, Schork A, Scott JG, Scott KM, Stedman T, Sørensen HJ, Werge T, Whiteford HA, Laursen TM, Agerbo E, Kessler RC, Mortensen PB, McGrath JJ. 2019. Exploring Comorbidity Within Mental Disorders Among a Danish National Population. JAMA Psychiatry. https://doi.org/10.1001/jamapsychiatry.2018.3658

MLA

Vancouver

Author

Plana-Ripoll, Oleguer ; Pedersen, Carsten Bøcker ; Holtz, Yan ; Benros, Michael E ; Dalsgaard, Søren ; de Jonge, Peter ; Fan, Chun Chieh ; Degenhardt, Louisa ; Ganna, Andrea ; Greve, Aja Neergaard ; Gunn, Jane ; Iburg, Kim Moesgaard ; Kessing, Lars Vedel ; Lee, Brian K ; Lim, Carmen C W ; Mors, Ole ; Nordentoft, Merete ; Prior, Anders ; Roest, Annelieke M ; Saha, Sukanta ; Schork, Andrew ; Scott, James G ; Scott, Kate M ; Stedman, Terry ; Sørensen, Holger J ; Werge, Thomas ; Whiteford, Harvey A ; Laursen, Thomas Munk ; Agerbo, Esben ; Kessler, Ronald C ; Mortensen, Preben Bo ; McGrath, John J. / Exploring Comorbidity Within Mental Disorders Among a Danish National Population. In: JAMA Psychiatry. 2019.

Bibtex

@article{d2f97c96057e4dcd8ad7084967d4630b,
title = "Exploring Comorbidity Within Mental Disorders Among a Danish National Population",
abstract = "Importance: Individuals with mental disorders often develop comorbidity over time. Past studies of comorbidity have often restricted analyses to a subset of disorders and few studies have provided absolute risks of later comorbidity.Objectives: To undertake a comprehensive study of comorbidity within mental disorders, by providing temporally ordered age- and sex-specific pairwise estimates between the major groups of mental disorders, and to develop an interactive website to visualize all results and guide future research and clinical practice.Design, Setting, and Participants: This population-based cohort study included all individuals born in Denmark between January 1, 1900, and December 31, 2015, and living in the country between January 1, 2000, and December 31, 2016. The analyses were conducted between June 2017 and May 2018.Main Outcomes and Measures: Danish health registers were used to identify mental disorders, which were examined within the broad 10-level International Statistical Classification of Diseases and Related Health Problems, 10th Revision, subchapter groups (eg, codes F00-F09 and F10-F19). For each temporally ordered pair of disorders, overall and lagged hazard ratios and 95{\%} CIs were calculated using Cox proportional hazards regression models. Absolute risks were estimated using competing risks survival analyses. Estimates for each sex were generated.Results: A total of 5 940 778 persons were included in this study (2 958 293 men and 2 982 485 women; mean [SD] age at beginning of follow-up, 32.1 [25.4] years). They were followed up for 83.9 million person-years. All mental disorders were associated with an increased risk of all other mental disorders when adjusting for sex, age, and calendar time (hazard ratios ranging from 2.0 [95{\%} CI, 1.7-2.4] for prior intellectual disabilities and later eating disorders to 48.6 [95{\%} CI, 46.6-50.7] for prior developmental disorders and later intellectual disabilities). The hazard ratios were temporally patterned, with higher estimates during the first year after the onset of the first disorder, but with persistently elevated rates during the entire observation period. Some disorders were associated with substantial absolute risks of developing specific later disorders (eg, 30.6{\%} [95{\%} CI, 29.3{\%}-32.0{\%}] of men and 38.4{\%} [95{\%} CI, 37.5{\%}-39.4{\%}] of women with a diagnosis of mood disorders before age 20 years developed neurotic disorders within the following 5 years).Conclusions and Relevance: Comorbidity within mental disorders is pervasive, and the risk persists over time. This study provides disorder-, sex-, and age-specific relative and absolute risks of the comorbidity of mental disorders. Web-based interactive data visualization tools are provided for clinical utility.",
author = "Oleguer Plana-Ripoll and Pedersen, {Carsten B{\o}cker} and Yan Holtz and Benros, {Michael E} and S{\o}ren Dalsgaard and {de Jonge}, Peter and Fan, {Chun Chieh} and Louisa Degenhardt and Andrea Ganna and Greve, {Aja Neergaard} and Jane Gunn and Iburg, {Kim Moesgaard} and Kessing, {Lars Vedel} and Lee, {Brian K} and Lim, {Carmen C W} and Ole Mors and Merete Nordentoft and Anders Prior and Roest, {Annelieke M} and Sukanta Saha and Andrew Schork and Scott, {James G} and Scott, {Kate M} and Terry Stedman and S{\o}rensen, {Holger J} and Thomas Werge and Whiteford, {Harvey A} and Laursen, {Thomas Munk} and Esben Agerbo and Kessler, {Ronald C} and Mortensen, {Preben Bo} and McGrath, {John J}",
year = "2019",
month = "1",
day = "16",
doi = "10.1001/jamapsychiatry.2018.3658",
language = "English",
journal = "Archives of General Psychiatry",
issn = "2168-622X",
publisher = "American Medical Association",

}

RIS

TY - JOUR

T1 - Exploring Comorbidity Within Mental Disorders Among a Danish National Population

AU - Plana-Ripoll, Oleguer

AU - Pedersen, Carsten Bøcker

AU - Holtz, Yan

AU - Benros, Michael E

AU - Dalsgaard, Søren

AU - de Jonge, Peter

AU - Fan, Chun Chieh

AU - Degenhardt, Louisa

AU - Ganna, Andrea

AU - Greve, Aja Neergaard

AU - Gunn, Jane

AU - Iburg, Kim Moesgaard

AU - Kessing, Lars Vedel

AU - Lee, Brian K

AU - Lim, Carmen C W

AU - Mors, Ole

AU - Nordentoft, Merete

AU - Prior, Anders

AU - Roest, Annelieke M

AU - Saha, Sukanta

AU - Schork, Andrew

AU - Scott, James G

AU - Scott, Kate M

AU - Stedman, Terry

AU - Sørensen, Holger J

AU - Werge, Thomas

AU - Whiteford, Harvey A

AU - Laursen, Thomas Munk

AU - Agerbo, Esben

AU - Kessler, Ronald C

AU - Mortensen, Preben Bo

AU - McGrath, John J

PY - 2019/1/16

Y1 - 2019/1/16

N2 - Importance: Individuals with mental disorders often develop comorbidity over time. Past studies of comorbidity have often restricted analyses to a subset of disorders and few studies have provided absolute risks of later comorbidity.Objectives: To undertake a comprehensive study of comorbidity within mental disorders, by providing temporally ordered age- and sex-specific pairwise estimates between the major groups of mental disorders, and to develop an interactive website to visualize all results and guide future research and clinical practice.Design, Setting, and Participants: This population-based cohort study included all individuals born in Denmark between January 1, 1900, and December 31, 2015, and living in the country between January 1, 2000, and December 31, 2016. The analyses were conducted between June 2017 and May 2018.Main Outcomes and Measures: Danish health registers were used to identify mental disorders, which were examined within the broad 10-level International Statistical Classification of Diseases and Related Health Problems, 10th Revision, subchapter groups (eg, codes F00-F09 and F10-F19). For each temporally ordered pair of disorders, overall and lagged hazard ratios and 95% CIs were calculated using Cox proportional hazards regression models. Absolute risks were estimated using competing risks survival analyses. Estimates for each sex were generated.Results: A total of 5 940 778 persons were included in this study (2 958 293 men and 2 982 485 women; mean [SD] age at beginning of follow-up, 32.1 [25.4] years). They were followed up for 83.9 million person-years. All mental disorders were associated with an increased risk of all other mental disorders when adjusting for sex, age, and calendar time (hazard ratios ranging from 2.0 [95% CI, 1.7-2.4] for prior intellectual disabilities and later eating disorders to 48.6 [95% CI, 46.6-50.7] for prior developmental disorders and later intellectual disabilities). The hazard ratios were temporally patterned, with higher estimates during the first year after the onset of the first disorder, but with persistently elevated rates during the entire observation period. Some disorders were associated with substantial absolute risks of developing specific later disorders (eg, 30.6% [95% CI, 29.3%-32.0%] of men and 38.4% [95% CI, 37.5%-39.4%] of women with a diagnosis of mood disorders before age 20 years developed neurotic disorders within the following 5 years).Conclusions and Relevance: Comorbidity within mental disorders is pervasive, and the risk persists over time. This study provides disorder-, sex-, and age-specific relative and absolute risks of the comorbidity of mental disorders. Web-based interactive data visualization tools are provided for clinical utility.

AB - Importance: Individuals with mental disorders often develop comorbidity over time. Past studies of comorbidity have often restricted analyses to a subset of disorders and few studies have provided absolute risks of later comorbidity.Objectives: To undertake a comprehensive study of comorbidity within mental disorders, by providing temporally ordered age- and sex-specific pairwise estimates between the major groups of mental disorders, and to develop an interactive website to visualize all results and guide future research and clinical practice.Design, Setting, and Participants: This population-based cohort study included all individuals born in Denmark between January 1, 1900, and December 31, 2015, and living in the country between January 1, 2000, and December 31, 2016. The analyses were conducted between June 2017 and May 2018.Main Outcomes and Measures: Danish health registers were used to identify mental disorders, which were examined within the broad 10-level International Statistical Classification of Diseases and Related Health Problems, 10th Revision, subchapter groups (eg, codes F00-F09 and F10-F19). For each temporally ordered pair of disorders, overall and lagged hazard ratios and 95% CIs were calculated using Cox proportional hazards regression models. Absolute risks were estimated using competing risks survival analyses. Estimates for each sex were generated.Results: A total of 5 940 778 persons were included in this study (2 958 293 men and 2 982 485 women; mean [SD] age at beginning of follow-up, 32.1 [25.4] years). They were followed up for 83.9 million person-years. All mental disorders were associated with an increased risk of all other mental disorders when adjusting for sex, age, and calendar time (hazard ratios ranging from 2.0 [95% CI, 1.7-2.4] for prior intellectual disabilities and later eating disorders to 48.6 [95% CI, 46.6-50.7] for prior developmental disorders and later intellectual disabilities). The hazard ratios were temporally patterned, with higher estimates during the first year after the onset of the first disorder, but with persistently elevated rates during the entire observation period. Some disorders were associated with substantial absolute risks of developing specific later disorders (eg, 30.6% [95% CI, 29.3%-32.0%] of men and 38.4% [95% CI, 37.5%-39.4%] of women with a diagnosis of mood disorders before age 20 years developed neurotic disorders within the following 5 years).Conclusions and Relevance: Comorbidity within mental disorders is pervasive, and the risk persists over time. This study provides disorder-, sex-, and age-specific relative and absolute risks of the comorbidity of mental disorders. Web-based interactive data visualization tools are provided for clinical utility.

U2 - 10.1001/jamapsychiatry.2018.3658

DO - 10.1001/jamapsychiatry.2018.3658

M3 - Journal article

JO - Archives of General Psychiatry

JF - Archives of General Psychiatry

SN - 2168-622X

ER -

ID: 56346045