Exploration of Plasma Lipids in Mild Cognitive Impairment due to Alzheimer's Disease

Anne Katrine Bergland*, Petroula Proitsi, Bjørn Eivind Kirsebom, Hogne Soennesyn, Abdul Hye, Alf Inge Larsen, Jin Xu, Cristina Legido-Quigley, Lawrence Rajendran, Tormod Fladby, Dag Aarsland

*Corresponding author for this work
8 Citations (Scopus)


Background: Lipids have important structural roles in cell membranes and changes to these membrane lipids may influence β- and γ-secretase activities and thus contribute to Alzheimer's disease (AD) pathology. Objective: To explore baseline plasma lipid profiling in participants with mild cognitive impairment (MCI) with and without AD pathology. Methods: We identified 261 plasma lipids using reversed-phase liquid chromatography/mass spectrometry in cerebrospinal fluid amyloid positive (Aβ+) or negative (Aβ-) participants with MCI as compared to controls. Additionally, we analyzed the potential associations of plasma lipid profiles with performance on neuropsychological tests at baseline and after two years. Results: Sphingomyelin (SM) concentrations, particularly, SM(d43:2), were lower in MCI Aβ+ individuals compared to controls. Further, SM(d43:2) was also nominally reduced in MCI Aβ+ individuals compared to MCI Aβ-. No plasma lipids were associated with performance on primary neuropsychological tests at baseline or between the two time points after correction for multiple testing. Conclusion: Reduced plasma concentrations of SM were associated with AD.

Original languageEnglish
JournalJournal of Alzheimer's Disease
Issue number3
Pages (from-to)1117-1127
Number of pages11
Publication statusPublished - 2020


  • Alzheimer's disease
  • lipid
  • mild cognitive impairment
  • sphingomyelin


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