Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Expert consensus on optimal acquisition and development of the International Bowel Ultrasound Segmental Activity Score (IBUS-SAS): a reliability and inter-rater variability study on intestinal ultrasonography in Crohn's Disease

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. The Incidence and Disease Course of Perianal Crohn's Disease: A Danish Nationwide Cohort Study, 1997-2015

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Corrigendum to: Diagnostic Yield of Next-Generation Sequencing in Very Early-Onset Inflammatory Bowel Diseases: A Multicenter Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Quality of care standards in inflammatory bowel diseases: a European Crohn's and Colitis Organisation (ECCO) position paper

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The Sooner the Better? Cost-effectiveness of Early Biological Therapy in Patients With Crohn's Disease

    Research output: Contribution to journalEditorialpeer-review

  1. Diagnostic accuracy of MRE and ultrasound for Crohn's disease

    Research output: Contribution to journalLetterpeer-review

  • Kerri L Novak
  • Kim Nylund
  • Christian Maaser
  • Frauke Petersen
  • Torsten Kucharzik
  • Cathy Lu
  • Mariangela Allocca
  • Giovanni Maconi
  • Floris de Voogd
  • Britt Christensen
  • Rose Vaughan
  • Carolina Palmela
  • Dan Carter
  • Rune Wilkens
View graph of relations

BACKGROUND AND AIMS: Intestinal ultrasound [IUS] is an accurate, patient-centreed monitoring tool that objectively evaluates Crohn's disease [CD] activity. However no current, widely accepted, reproducible activity index exists to facilitate consistent IUS identification of inflammatory activity. The aim of this study is to identify key parameters of CD inflammation on IUS, evaluate their reliability, and develop an IUS index reflecting segmental activity.

METHODS: There were three phases: [1] expert consensus Delphi method to derive measures of IUS activity; [2] an initial, multi-expert case acquisition and expert interpretation of 20 blinded cases, to measure inter-rater reliability for individual measures; [3] refinement of case acquisition and interpretation by 12 international experts, with 30 blinded case reads with reliability assessment and development of a segmental activity score.

RESULTS: Delphi consensus: 11 experts representing seven countries identified four key parameters including: [1] bowel wall thickness [BWT]; [2] bowel wall stratification; [3] hyperaemia of the wall [colour Doppler imaging]; and [4] inflammatory mesenteric fat. Blind read: each variable exhibited moderate to substantial reliability. Optimal, standardised image and cineloop acquisition were established. Second blind read and score development: intra-class correlation coefficient [ICC] for BWT was almost perfect at 0.96 [0.94-0.98]. All four parameters correlated with the global disease activity assessment and were included in the final International Bowel Ultrasound Segmental Activity Score with almost perfect ICC (0.97 [0.95-0.99, p <0.001]).

CONCLUSIONS: Using expert consensus and standardised approaches, identification of key activity measurements on IUS has been achieved and a segmental activity score has been proposed, demonstrating excellent reliability.

Original languageEnglish
JournalJournal of Crohn's & colitis
Volume15
Issue number4
Pages (from-to)609-616
Number of pages8
ISSN1873-9946
DOIs
Publication statusPublished - 6 Apr 2021

ID: 61112773