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Experimental knee pain evoke spreading hyperalgesia and facilitated temporal summation of pain

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@article{bdfdc8d3de2c450bbcaea6b4e710494d,
title = "Experimental knee pain evoke spreading hyperalgesia and facilitated temporal summation of pain",
abstract = "OBJECTIVES: This study evaluated the deep-tissue pressure pain sensitivity and temporal summation of pain within and around healthy knees exposed to experimental pain.DESIGN: The study was designed as a randomized crossover trial, with each subject tested on 1 day.SETTING: All tests were carried out at the Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction, Department of Health Science and Technology at Aalborg University, Denmark.SUBJECTS: Seventeen healthy subjects (10 males) participated in this study.INTERVENTIONS: Experimental pain model. Pain was induced in the infrapatellar fat pad by injection of hypertonic saline and the contralateral infrapatellar fat pad was injected with isotonic saline as control.OUTCOME MEASURES: Pressure pain thresholds, temporal summation of pressure pain, and cutaneous mechanosensitivity were assessed on three occasions: baseline, immediately after the injection, and when pain had vanished. Assessments sites were located in the peripatellar region, vastus lateralis, and tibialis anterior muscles.RESULTS: The experimental knee pain model demonstrated 1) hyperalgesia to pressure stimulation on the infrapatellar fat pad during experimental pain, and 2) facilitated temporal summation of pressure pain at the infrapatellar fat pad and knee-related muscles.CONCLUSION: The increased sensitivity and temporal summation found in this study were exclusive to deep -tissue with no contralateral decreased pain sensitivity. The study showed that acute knee joint pain leads to hyperalgesia and facilitated temporal summation in the infrapatellar fat pad and in muscles located distant to the injection site, in subjects with no history of knee pain.",
keywords = "Adult, Arthralgia, Cross-Over Studies, Female, Humans, Hyperalgesia, Knee Joint, Male, Myalgia, Pain Threshold, Young Adult",
author = "Joergensen, {Tanja Schjoedt} and Marius Henriksen and Bente Danneskiold-Samsoee and Henning Bliddal and Thomas Graven-Nielsen",
note = "Wiley Periodicals, Inc.",
year = "2013",
month = "6",
doi = "10.1111/pme.12093",
language = "English",
volume = "14",
pages = "874--83",
journal = "Pain Medicine",
issn = "1526-2375",
publisher = "Wiley-Blackwell Publishing, Inc",
number = "6",

}

RIS

TY - JOUR

T1 - Experimental knee pain evoke spreading hyperalgesia and facilitated temporal summation of pain

AU - Joergensen, Tanja Schjoedt

AU - Henriksen, Marius

AU - Danneskiold-Samsoee, Bente

AU - Bliddal, Henning

AU - Graven-Nielsen, Thomas

N1 - Wiley Periodicals, Inc.

PY - 2013/6

Y1 - 2013/6

N2 - OBJECTIVES: This study evaluated the deep-tissue pressure pain sensitivity and temporal summation of pain within and around healthy knees exposed to experimental pain.DESIGN: The study was designed as a randomized crossover trial, with each subject tested on 1 day.SETTING: All tests were carried out at the Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction, Department of Health Science and Technology at Aalborg University, Denmark.SUBJECTS: Seventeen healthy subjects (10 males) participated in this study.INTERVENTIONS: Experimental pain model. Pain was induced in the infrapatellar fat pad by injection of hypertonic saline and the contralateral infrapatellar fat pad was injected with isotonic saline as control.OUTCOME MEASURES: Pressure pain thresholds, temporal summation of pressure pain, and cutaneous mechanosensitivity were assessed on three occasions: baseline, immediately after the injection, and when pain had vanished. Assessments sites were located in the peripatellar region, vastus lateralis, and tibialis anterior muscles.RESULTS: The experimental knee pain model demonstrated 1) hyperalgesia to pressure stimulation on the infrapatellar fat pad during experimental pain, and 2) facilitated temporal summation of pressure pain at the infrapatellar fat pad and knee-related muscles.CONCLUSION: The increased sensitivity and temporal summation found in this study were exclusive to deep -tissue with no contralateral decreased pain sensitivity. The study showed that acute knee joint pain leads to hyperalgesia and facilitated temporal summation in the infrapatellar fat pad and in muscles located distant to the injection site, in subjects with no history of knee pain.

AB - OBJECTIVES: This study evaluated the deep-tissue pressure pain sensitivity and temporal summation of pain within and around healthy knees exposed to experimental pain.DESIGN: The study was designed as a randomized crossover trial, with each subject tested on 1 day.SETTING: All tests were carried out at the Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction, Department of Health Science and Technology at Aalborg University, Denmark.SUBJECTS: Seventeen healthy subjects (10 males) participated in this study.INTERVENTIONS: Experimental pain model. Pain was induced in the infrapatellar fat pad by injection of hypertonic saline and the contralateral infrapatellar fat pad was injected with isotonic saline as control.OUTCOME MEASURES: Pressure pain thresholds, temporal summation of pressure pain, and cutaneous mechanosensitivity were assessed on three occasions: baseline, immediately after the injection, and when pain had vanished. Assessments sites were located in the peripatellar region, vastus lateralis, and tibialis anterior muscles.RESULTS: The experimental knee pain model demonstrated 1) hyperalgesia to pressure stimulation on the infrapatellar fat pad during experimental pain, and 2) facilitated temporal summation of pressure pain at the infrapatellar fat pad and knee-related muscles.CONCLUSION: The increased sensitivity and temporal summation found in this study were exclusive to deep -tissue with no contralateral decreased pain sensitivity. The study showed that acute knee joint pain leads to hyperalgesia and facilitated temporal summation in the infrapatellar fat pad and in muscles located distant to the injection site, in subjects with no history of knee pain.

KW - Adult

KW - Arthralgia

KW - Cross-Over Studies

KW - Female

KW - Humans

KW - Hyperalgesia

KW - Knee Joint

KW - Male

KW - Myalgia

KW - Pain Threshold

KW - Young Adult

U2 - 10.1111/pme.12093

DO - 10.1111/pme.12093

M3 - Journal article

VL - 14

SP - 874

EP - 883

JO - Pain Medicine

JF - Pain Medicine

SN - 1526-2375

IS - 6

ER -

ID: 44333163