Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Experimental knee pain evoke spreading hyperalgesia and facilitated temporal summation of pain

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Chronic Pain, Opioid Therapy, Sexual Desire, and Satisfaction in Sexual Life: A Population-Based Survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. No Effect of Acupuncture as Adjunctive Therapy for Patients with Total Knee Replacement: A Randomized Controlled Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Association of Physical Fitness with Depression in Women with Fibromyalgia

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Contact Heat Evoked Potentials (CHEPs) in Patients with Mild-Moderate Alzheimer's Disease and Matched Control-A Pilot Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Effects of Mindfulness Meditation on Chronic Pain: A Randomized Controlled Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Perfusion in bone marrow lesions assessed on DCE-MRI and its association with pain in knee osteoarthritis: a cross-sectional study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Associations between shoulder symptoms and concomitant pathology in patients with traumatic supraspinatus tears

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVES: This study evaluated the deep-tissue pressure pain sensitivity and temporal summation of pain within and around healthy knees exposed to experimental pain.

DESIGN: The study was designed as a randomized crossover trial, with each subject tested on 1 day.

SETTING: All tests were carried out at the Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction, Department of Health Science and Technology at Aalborg University, Denmark.

SUBJECTS: Seventeen healthy subjects (10 males) participated in this study.

INTERVENTIONS: Experimental pain model. Pain was induced in the infrapatellar fat pad by injection of hypertonic saline and the contralateral infrapatellar fat pad was injected with isotonic saline as control.

OUTCOME MEASURES: Pressure pain thresholds, temporal summation of pressure pain, and cutaneous mechanosensitivity were assessed on three occasions: baseline, immediately after the injection, and when pain had vanished. Assessments sites were located in the peripatellar region, vastus lateralis, and tibialis anterior muscles.

RESULTS: The experimental knee pain model demonstrated 1) hyperalgesia to pressure stimulation on the infrapatellar fat pad during experimental pain, and 2) facilitated temporal summation of pressure pain at the infrapatellar fat pad and knee-related muscles.

CONCLUSION: The increased sensitivity and temporal summation found in this study were exclusive to deep -tissue with no contralateral decreased pain sensitivity. The study showed that acute knee joint pain leads to hyperalgesia and facilitated temporal summation in the infrapatellar fat pad and in muscles located distant to the injection site, in subjects with no history of knee pain.

Original languageEnglish
JournalPain medicine (Malden, Mass.)
Volume14
Issue number6
Pages (from-to)874-83
Number of pages10
ISSN1526-2375
DOIs
Publication statusPublished - Jun 2013

    Research areas

  • Adult, Arthralgia, Cross-Over Studies, Female, Humans, Hyperalgesia, Knee Joint, Male, Myalgia, Pain Threshold, Young Adult

ID: 44333163