Exhaled Nitric Oxide in Premature and Mature Infants During the First Months of Life

Fanny E M Goth; Birgitte J Schmidt; Lone Agertoft; Inger Merete Jørgensen

doi:10.1016/j.niox.2021.04.005

Exhaled Nitric Oxide in Premature and Mature Infants During the First Months of Life

Fanny E M Goth, Birgitte J Schmidt, Lone Agertoft, Inger Merete Jørgensen

3 Citations (Scopus)

Abstract

Aim: In this review, we aim to describe how exhaled Nitric Oxide(NO) changes during the first months of life in premature and mature infants. Method: Review of the literature up to August 2020, on online, tidal breathing NO measurements in unsedated infants. The association between Fractional exhaled NO(FeNO) values, postnatal age, and prematurity was analysed using linear mixed modeling and Spearman's rank correlation. Results: Median FeNO during the first months of life was 5.9 and 8.5 ppb in premature and mature infants, respectively. The linear mixed model analysis showed a significant effect of postnatal age on FeNO (p = 0.007). Conclusion: Our study suggests that FeNO is higher in mature infants than premature infants, and FeNO increased with postnatal age at approximately the same pace in both groups.

Original language	English
Journal	Nitric Oxide: Biology and Chemistry
Volume	113-114
Pages (from-to)	7-12
Number of pages	6
ISSN	1089-8603
DOIs	https://doi.org/10.1016/j.niox.2021.04.005
Publication status	Published - 1 Sept 2021

Keywords

Exhaled nitric oxide
Lung development
Neonatal
Premature
Humans
Nitric Oxide/analysis
Breath Tests
Infant
Exhalation

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10.1016/j.niox.2021.04.005

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title = "Exhaled Nitric Oxide in Premature and Mature Infants During the First Months of Life",

abstract = "Aim: In this review, we aim to describe how exhaled Nitric Oxide(NO) changes during the first months of life in premature and mature infants. Method: Review of the literature up to August 2020, on online, tidal breathing NO measurements in unsedated infants. The association between Fractional exhaled NO(FeNO) values, postnatal age, and prematurity was analysed using linear mixed modeling and Spearman's rank correlation. Results: Median FeNO during the first months of life was 5.9 and 8.5 ppb in premature and mature infants, respectively. The linear mixed model analysis showed a significant effect of postnatal age on FeNO (p = 0.007). Conclusion: Our study suggests that FeNO is higher in mature infants than premature infants, and FeNO increased with postnatal age at approximately the same pace in both groups.",

keywords = "Exhaled nitric oxide, Lung development, Neonatal, Premature, Humans, Nitric Oxide/analysis, Breath Tests, Infant, Exhalation",

author = "Goth, {Fanny E M} and Schmidt, {Birgitte J} and Lone Agertoft and J{\o}rgensen, {Inger Merete}",

year = "2021",

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doi = "10.1016/j.niox.2021.04.005",

language = "English",

volume = "113-114",

pages = "7--12",

journal = "Nitric Oxide: Biology and Chemistry",

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T1 - Exhaled Nitric Oxide in Premature and Mature Infants During the First Months of Life

AU - Goth, Fanny E M

AU - Schmidt, Birgitte J

AU - Agertoft, Lone

AU - Jørgensen, Inger Merete

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Aim: In this review, we aim to describe how exhaled Nitric Oxide(NO) changes during the first months of life in premature and mature infants. Method: Review of the literature up to August 2020, on online, tidal breathing NO measurements in unsedated infants. The association between Fractional exhaled NO(FeNO) values, postnatal age, and prematurity was analysed using linear mixed modeling and Spearman's rank correlation. Results: Median FeNO during the first months of life was 5.9 and 8.5 ppb in premature and mature infants, respectively. The linear mixed model analysis showed a significant effect of postnatal age on FeNO (p = 0.007). Conclusion: Our study suggests that FeNO is higher in mature infants than premature infants, and FeNO increased with postnatal age at approximately the same pace in both groups.

AB - Aim: In this review, we aim to describe how exhaled Nitric Oxide(NO) changes during the first months of life in premature and mature infants. Method: Review of the literature up to August 2020, on online, tidal breathing NO measurements in unsedated infants. The association between Fractional exhaled NO(FeNO) values, postnatal age, and prematurity was analysed using linear mixed modeling and Spearman's rank correlation. Results: Median FeNO during the first months of life was 5.9 and 8.5 ppb in premature and mature infants, respectively. The linear mixed model analysis showed a significant effect of postnatal age on FeNO (p = 0.007). Conclusion: Our study suggests that FeNO is higher in mature infants than premature infants, and FeNO increased with postnatal age at approximately the same pace in both groups.

KW - Exhaled nitric oxide

KW - Lung development

KW - Neonatal

KW - Premature

KW - Humans

KW - Nitric Oxide/analysis

KW - Breath Tests

KW - Infant

KW - Exhalation

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DO - 10.1016/j.niox.2021.04.005

M3 - Review

C2 - 33866006

SN - 1089-8603

VL - 113-114

SP - 7

EP - 12

JO - Nitric Oxide: Biology and Chemistry

JF - Nitric Oxide: Biology and Chemistry

ER -

Exhaled Nitric Oxide in Premature and Mature Infants During the First Months of Life

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Keywords

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