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Exercise protects from cancer through regulation of immune function and inflammation

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Exercise training has been extensively studied in cancer settings as part of prevention or rehabilitation strategies, yet emerging evidence suggests that exercise training can also directly affect tumor-specific outcomes. The underlying mechanisms for this exercise-dependent cancer protection are just starting to be elucidated. To this end, evasion of immune surveillance and tumor-associated inflammation are established as hallmarks of cancer, and exercise may target cancer incidence and progression through regulation of these mechanisms. Here, I review the role of exercise in protection from cancer through mobilization and activation of cytotoxic immune cells, restriction of inflammatory signaling pathways in myeloid immune cells, and regulation of acute and chronic systemic inflammatory responses. In conclusion, I propose that exercise has the potential to target tumor growth through regulation of immune and inflammatory functions, and exercise may be pursued as anticancer treatment through incorporation into standard oncological therapy to the benefit of the cancer patients.

Original languageEnglish
JournalBiochemical Society Transactions
Volume45
Issue number4
Pages (from-to)905-11
Number of pages7
ISSN0300-5127
DOIs
Publication statusPublished - 15 Aug 2017

    Research areas

  • Animals, Carcinogenesis, Combined Modality Therapy, Cytokines, Cytotoxicity, Immunologic, Down-Regulation, Evidence-Based Medicine, Exercise, Humans, Immunity, Cellular, Immunologic Surveillance, Lymphocyte Activation, Models, Immunological, Myeloid Cells, Neoplasms, T-Lymphocytes, Cytotoxic, Journal Article, Review

ID: 52608367