Abstract
TNF-alpha is linked with insulin resistance, as greater amounts of TNF are detected in muscle and adipose tissue in glycemically challenged people and TNF-alpha inhibits insulin receptor signalling. However, what modulates this overexpression of TNF-alpha is currently unknown. We examined the effect of 1 h exercise on overexpression of the TNF-alpha gene in TNF receptor 1 and 2 knockout mice. IL-6 knockout mice were included to elucidate the importance of IL-6 in regulating TNF-alpha in response to exercise. TNF-alpha gene expression was over-expressed in muscle in both TNFR knockout models. TNF-alpha overexpression returned to normal levels after exercise in the TNF-alpha receptor knockout models. In IL-6 knockout mice, a modest decrease in TNF-alpha was also observed. These data suggest that TNF-alpha-induced insulin resistance can be regulated by a single exercise bout by normalising TNF-alpha expression. This exercise effect can be mediated via IL-6, but also an IL-6 independent mechanism seems to exist.
| Original language | English |
|---|---|
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 321 |
| Issue number | 1 |
| Pages (from-to) | 179-82 |
| Number of pages | 4 |
| ISSN | 0006-291X |
| DOIs | |
| Publication status | Published - 13 Aug 2004 |
| Externally published | Yes |
Keywords
- Adipose Tissue/physiology
- Animals
- Antigens, CD/genetics
- Female
- Insulin Resistance/genetics
- Interleukin-6/deficiency
- Male
- Mice
- Mice, Knockout
- Muscle, Skeletal/physiology
- Physical Conditioning, Animal/physiology
- RNA, Messenger/genetics
- Receptors, Tumor Necrosis Factor/deficiency
- Receptors, Tumor Necrosis Factor, Type I
- Receptors, Tumor Necrosis Factor, Type II
- Tumor Necrosis Factor-alpha/genetics
Fingerprint
Dive into the research topics of 'Exercise normalises overexpression of TNF-alpha in knockout mice'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS