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Exercise and cancer: from "healthy" to "therapeutic"?

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@article{34eb3e726d714d0a873e2fe5ffaee634,
title = "Exercise and cancer: from {"}healthy{"} to {"}therapeutic{"}?",
abstract = "Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be {"}healthy{"} but may in fact be therapeutic.",
keywords = "Exercise, Exercise Therapy, Humans, Neoplasms, Journal Article, Review",
author = "Manja Idorn and {Thor Straten}, Per",
year = "2017",
month = may,
doi = "10.1007/s00262-017-1985-z",
language = "English",
volume = "66",
pages = "667--671",
journal = "Cancer Immunology and Immunotherapy",
issn = "0340-7004",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Exercise and cancer

T2 - from "healthy" to "therapeutic"?

AU - Idorn, Manja

AU - Thor Straten, Per

PY - 2017/5

Y1 - 2017/5

N2 - Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be "healthy" but may in fact be therapeutic.

AB - Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be "healthy" but may in fact be therapeutic.

KW - Exercise

KW - Exercise Therapy

KW - Humans

KW - Neoplasms

KW - Journal Article

KW - Review

U2 - 10.1007/s00262-017-1985-z

DO - 10.1007/s00262-017-1985-z

M3 - Review

C2 - 28324125

VL - 66

SP - 667

EP - 671

JO - Cancer Immunology and Immunotherapy

JF - Cancer Immunology and Immunotherapy

SN - 0340-7004

IS - 5

ER -

ID: 52221612