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Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass

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Roux-en-Y gastric bypass (RYGB) improves glycaemic control in part by increasing postprandial insulin secretion through exaggerated glucagon-like peptide (GLP)-1 release. However, it is unknown whether islet cell responsiveness to i.v. glucose, non-glucose (arginine) and incretin hormones, including GLP-1, is altered.
Original languageEnglish
JournalDiabetologia
Volume56
Issue number12
Pages (from-to)2679-87
Number of pages9
ISSN0012-186X
DOIs
Publication statusPublished - Dec 2013

ID: 41764200