Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass

Carsten Dirksen; Kirstine N Bojsen-Møller; Nils B Jørgensen; Siv H Jacobsen; Viggo B Kristiansen; Lars S Naver; Dorte L Hansen; Dorte Worm; Jens Juul Holst; Sten Madsbad

doi:10.1007/s00125-013-3055-1

Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass

Carsten Dirksen, Kirstine N Bojsen-Møller, Nils B Jørgensen, Siv H Jacobsen, Viggo B Kristiansen, Lars S Naver, Dorte L Hansen, Dorte Worm, Jens Juul Holst, Sten Madsbad

87 Citations (Scopus)

Abstract

Roux-en-Y gastric bypass (RYGB) improves glycaemic control in part by increasing postprandial insulin secretion through exaggerated glucagon-like peptide (GLP)-1 release. However, it is unknown whether islet cell responsiveness to i.v. glucose, non-glucose (arginine) and incretin hormones, including GLP-1, is altered.

Original language	English
Journal	Diabetologia
Volume	56
Issue number	12
Pages (from-to)	2679-87
Number of pages	9
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-013-3055-1
Publication status	Published - Dec 2013

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Dirksen, C., Bojsen-Møller, K. N., Jørgensen, N. B., Jacobsen, S. H., Kristiansen, V. B., Naver, L. S., Hansen, D. L., Worm, D., Holst, J. J., & Madsbad, S. (2013). Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass. Diabetologia, 56(12), 2679-87. https://doi.org/10.1007/s00125-013-3055-1

Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass. / Dirksen, Carsten ; Bojsen-Møller, Kirstine N; Jørgensen, Nils B et al.
In: Diabetologia, Vol. 56, No. 12, 12.2013, p. 2679-87.

Research output: Contribution to journal › Journal article › Research › peer-review

Dirksen, C , Bojsen-Møller, KN, Jørgensen, NB, Jacobsen, SH , Kristiansen, VB, Naver, LS, Hansen, DL , Worm, D, Holst, JJ & Madsbad, S 2013, 'Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass', Diabetologia, vol. 56, no. 12, pp. 2679-87. https://doi.org/10.1007/s00125-013-3055-1

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abstract = "Roux-en-Y gastric bypass (RYGB) improves glycaemic control in part by increasing postprandial insulin secretion through exaggerated glucagon-like peptide (GLP)-1 release. However, it is unknown whether islet cell responsiveness to i.v. glucose, non-glucose (arginine) and incretin hormones, including GLP-1, is altered.",

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AU - Jørgensen, Nils B

AU - Jacobsen, Siv H

AU - Kristiansen, Viggo B

AU - Naver, Lars S

AU - Hansen, Dorte L

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AU - Holst, Jens Juul

AU - Madsbad, Sten

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AB - Roux-en-Y gastric bypass (RYGB) improves glycaemic control in part by increasing postprandial insulin secretion through exaggerated glucagon-like peptide (GLP)-1 release. However, it is unknown whether islet cell responsiveness to i.v. glucose, non-glucose (arginine) and incretin hormones, including GLP-1, is altered.

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Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass

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