Abstract
Bleeding complications after cardiac surgery are of particular importance in children because they are more prone to volume overload. To optimize haemostatic intervention, the coagulopathy has to be characterized, and knowledge about the effect of blood products and haemostatic agents is needed. The aims of the present study were to investigate changes in coagulation profiles after paediatric cardiac surgery and the effect after ex-vivo addition of blood products and haemostatic agents. Coagulation profiles were evaluated by thromboelastometry (ROTEM) in 54 children before and immediately after cardiac surgery. The haemostatic potential of various factor concentrates (fibrinogen concentrate, recombinant factor VIIa and factor XIII), fresh frozen plasma (FFP), pooled platelets and tranexamic acid was investigated. After surgery, the coagulation profiles revealed significantly prolonged clotting time (P=0.008), and reduced clot propagation (P
| Original language | English |
|---|---|
| Journal | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis |
| Volume | 24 |
| Issue number | 6 |
| Pages (from-to) | 587-92 |
| Number of pages | 6 |
| ISSN | 0957-5235 |
| DOIs | |
| Publication status | Published - Sept 2013 |
| Externally published | Yes |