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Evidence connecting old, new and neglected glucose-lowering drugs to bile acid-induced GLP-1 secretion: A review

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DOI

  1. Is glucagon-like peptide-1 fully protected by dipeptidyl peptidase 4 inhibitor administration in patients with type 2 diabetes?

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  2. Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer

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  3. Cardiovascular biomarkers in clinical studies of type 2 diabetes

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  1. GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2

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  2. Gluco-metabolic effects of pharmacotherapy-induced modulation of bile acid physiology

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  3. Effect of the incretin hormones on the endocrine pancreas in end-stage renal disease

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  4. N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis

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Bile acids are amphipathic water-soluble steroid-based molecules best known for their important lipid-solubilizing role in the assimilation of fat. Recently, bile acids have emerged as metabolic integrators with glucose-lowering potential. Among a variety of gluco-metabolic effects, bile acids have been demonstrated to modulate the secretion of the gut-derived incretin hormone glucagon-like peptide-1 (GLP-1), possibly via the transmembrane receptor Takeda G-protein-coupled receptor 5 and the nuclear farnesoid X receptor, in intestinal L cells. The present article critically reviews current evidence connecting established glucose-lowering drugs to bile acid-induced GLP-1 secretion, and discusses whether bile acid-induced GLP-1 secretion may constitute a new basis for understanding how metformin, inhibitors of the apical sodium-dependent bile acids transporter, and bile acid sequestrants - old, new and neglected glucose-lowering drugs - improve glucose metabolism.

Original languageEnglish
JournalDiabetes, Obesity and Metabolism
Pages (from-to)1214-1222
Number of pages8
ISSN1462-8902
DOIs
Publication statusPublished - Sep 2017

    Research areas

  • Journal Article, Review

ID: 51454608