Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects

Britt Mejer Christensen; Carsten Lundby; Niels Jessen; Thomas Svava Nielsen; Poul F Vestergaard; Niels Møller; Henriette Pilegaard; Erik Steen Pedersen; John J Kopchick; Jens Otto Lunde Jørgensen

doi:10.1371/journal.pone.0031857

Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects

Britt Mejer Christensen, Carsten Lundby, Niels Jessen, Thomas Svava Nielsen, Poul F Vestergaard, Niels Møller, Henriette Pilegaard, Erik Steen Pedersen, John J Kopchick, Jens Otto Lunde Jørgensen

15 Citations (Scopus)

Abstract

Erythropoietin receptors have been identified in human skeletal muscle tissue, but downstream signal transduction has not been investigated. We therefore studied in vivo effects of systemic erythropoietin exposure in human skeletal muscle.

Original language	English
Journal	P L o S One
Volume	7
Issue number	2
Pages (from-to)	e31857
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0031857
Publication status	Published - 2012

Keywords

Adult
Biopsy
Electrophoresis, Gel, Two-Dimensional
Erythropoietin
Humans
Male
Mass Spectrometry
Muscle, Skeletal
Oxygen
Phosphorylation
Polymerase Chain Reaction
Protein Isoforms
Proteomics
RNA, Messenger
Receptors, Erythropoietin
Recombinant Proteins
Signal Transduction
Time Factors

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Christensen, B. M., Lundby, C., Jessen, N., Nielsen, T. S., Vestergaard, P. F., Møller, N., Pilegaard, H., Pedersen, E. S., Kopchick, J. J., & Jørgensen, J. O. L. (2012). Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects. P L o S One, 7(2), e31857. https://doi.org/10.1371/journal.pone.0031857

Christensen, BM, Lundby, C, Jessen, N, Nielsen, TS, Vestergaard, PF, Møller, N, Pilegaard, H, Pedersen, ES, Kopchick, JJ & Jørgensen, JOL 2012, 'Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects', P L o S One, vol. 7, no. 2, pp. e31857. https://doi.org/10.1371/journal.pone.0031857

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abstract = "Erythropoietin receptors have been identified in human skeletal muscle tissue, but downstream signal transduction has not been investigated. We therefore studied in vivo effects of systemic erythropoietin exposure in human skeletal muscle.",

keywords = "Adult, Biopsy, Electrophoresis, Gel, Two-Dimensional, Erythropoietin, Humans, Male, Mass Spectrometry, Muscle, Skeletal, Oxygen, Phosphorylation, Polymerase Chain Reaction, Protein Isoforms, Proteomics, RNA, Messenger, Receptors, Erythropoietin, Recombinant Proteins, Signal Transduction, Time Factors",

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AU - Christensen, Britt Mejer

AU - Lundby, Carsten

AU - Jessen, Niels

AU - Nielsen, Thomas Svava

AU - Vestergaard, Poul F

AU - Møller, Niels

AU - Pilegaard, Henriette

AU - Pedersen, Erik Steen

AU - Kopchick, John J

AU - Jørgensen, Jens Otto Lunde

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KW - Erythropoietin

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KW - Male

KW - Mass Spectrometry

KW - Muscle, Skeletal

KW - Oxygen

KW - Phosphorylation

KW - Polymerase Chain Reaction

KW - Protein Isoforms

KW - Proteomics

KW - RNA, Messenger

KW - Receptors, Erythropoietin

KW - Recombinant Proteins

KW - Signal Transduction

KW - Time Factors

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SP - e31857

JO - P L o S One

JF - P L o S One

IS - 2

ER -

Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects

Abstract

Keywords

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