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Evaluation of algorithm development approaches: Development of biomarker panels for early detection of colorectal lesions

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  1. Methodological development and biological observations of cell free DNA with a simple direct fluorescent assay in colorectal cancer

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  2. Clinical proteomics: Insights from IGF-I

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  3. Validation of image cytometry for sperm concentration measurement: Comparison with manual counting of 4010 human semen samples

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  4. Clinical usefulness of bone turnover marker concentrations in osteoporosis

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  5. Isotope-dilution TurboFlow-LC-MS/MS method for simultaneous quantification of ten steroid metabolites in serum

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  1. Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study

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  2. Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study

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  3. Genome-wide cell-free DNA fragmentation in patients with cancer

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  4. Mandibular advancement device therapy for obstructive sleep apnea: a prospective study on predictors of treatment success

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  • Danish Research Group on Early Detection of Colorectal Cancer
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INTRODUCTION: Colorectal cancer (CRC) is the third most common cancer in the U.S. Early detection of CRC can substantially increase survival rates. Test compliance may be improved by offering a blood-based test option.

METHODS: Endoscopy II trial specimens were tested for AFP, CA19-9, CEA, hs-CRP, CyFra 21-1, Ferritin, Galectin-3, and TIMP-1 levels. These biomarkers, as well as patient demographic information (e.g., age, gender), were included in algorithm development. Six statistical methods were utilized to develop algorithms that would discriminate cancer vs. noncancers. Statistical methods included logistic regression, adaptive index modeling, partial least-squares discriminant analysis, feature vector (weighted and unweighted), and random forest. The performance of these algorithms was compared against benchmark criteria established for stool-based tests.

RESULTS: Using several statistical methods, the presence of CRC and high-risk adenomas was detected with an AUCs of at least 0.65-0.76, with a few of models approaching the stool-based tests benchmark performance. Further, common markers were utilized across the different statistical techniques, with model complexities ranging from 3 to 9 markers.

CONCLUSIONS: Predictive models identified subjects with CRC and high-risk adenomas with the similar levels of statistical accuracy. Clinical performance differences were minimal across the statistical techniques, although the intuitive interpretations, model complexity, clinical adoption and implementation varied.

Original languageEnglish
JournalClinica chimica acta; international journal of clinical chemistry
Volume498
Pages (from-to)108-115
Number of pages8
ISSN0009-8981
DOIs
Publication statusPublished - Nov 2019

Bibliographical note

Copyright © 2019 Elsevier B.V. All rights reserved.

    Research areas

  • Algorithm methodologies, Biomarkers, Colon cancer, Early detection

ID: 57797982