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Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus

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Harvard

Legge, A, Kirkland, S, Rockwood, K, Andreou, P, Bae, S-C, Gordon, C, Romero-Diaz, J, Sanchez-Guerrero, J, Wallace, DJ, Bernatsky, S, Clarke, AE, Merrill, JT, Ginzler, EM, Fortin, P, Gladman, DD, Urowitz, MB, Bruce, IN, Isenberg, DA, Rahman, A, Alarcón, GS, Petri, M, Khamashta, MA, Dooley, MA, Ramsey-Goldman, R, Manzi, S, Steinsson, K, Zoma, AA, Aranow, C, Mackay, M, Ruiz-Irastorza, G, Lim, SS, Inanc, M, van Vollenhoven, RF, Jonsen, A, Nived, O, Ramos-Casals, M, Kamen, DL, Kalunian, KC, Jacobsen, S, Peschken, CA, Askanase, A & Hanly, JG 2019, 'Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus' Arthritis & rheumatology, vol. 71, no. 8, pp. 1297-1307. https://doi.org/10.1002/art.40859

APA

CBE

Legge A, Kirkland S, Rockwood K, Andreou P, Bae S-C, Gordon C, Romero-Diaz J, Sanchez-Guerrero J, Wallace DJ, Bernatsky S, Clarke AE, Merrill JT, Ginzler EM, Fortin P, Gladman DD, Urowitz MB, Bruce IN, Isenberg DA, Rahman A, Alarcón GS, Petri M, Khamashta MA, Dooley MA, Ramsey-Goldman R, Manzi S, Steinsson K, Zoma AA, Aranow C, Mackay M, Ruiz-Irastorza G, Lim SS, Inanc M, van Vollenhoven RF, Jonsen A, Nived O, Ramos-Casals M, Kamen DL, Kalunian KC, Jacobsen S, Peschken CA, Askanase A, Hanly JG. 2019. Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus. Arthritis & rheumatology. 71(8):1297-1307. https://doi.org/10.1002/art.40859

MLA

Vancouver

Author

Legge, Alexandra ; Kirkland, Susan ; Rockwood, Kenneth ; Andreou, Pantelis ; Bae, Sang-Cheol ; Gordon, Caroline ; Romero-Diaz, Juanita ; Sanchez-Guerrero, Jorge ; Wallace, Daniel J ; Bernatsky, Sasha ; Clarke, Ann E ; Merrill, Joan T ; Ginzler, Ellen M ; Fortin, Paul ; Gladman, Dafna D ; Urowitz, Murray B ; Bruce, Ian N ; Isenberg, David A ; Rahman, Anisur ; Alarcón, Graciela S ; Petri, Michelle ; Khamashta, Munther A ; Dooley, M A ; Ramsey-Goldman, Rosalind ; Manzi, Susan ; Steinsson, Kristjan ; Zoma, Asad A ; Aranow, Cynthia ; Mackay, Meggan ; Ruiz-Irastorza, Guillermo ; Lim, S Sam ; Inanc, Murat ; van Vollenhoven, Ronald F ; Jonsen, Andreas ; Nived, Ola ; Ramos-Casals, Manuel ; Kamen, Diane L ; Kalunian, Kenneth C ; Jacobsen, Soren ; Peschken, Christine A ; Askanase, Anca ; Hanly, John G. / Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus. In: Arthritis & rheumatology. 2019 ; Vol. 71, No. 8. pp. 1297-1307.

Bibtex

@article{4735b21953824ec5a9cb02e45e41914f,
title = "Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus",
abstract = "OBJECTIVE: To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in systemic lupus erythematosus (SLE).METHODS: For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36] scores) were assessed. The SLICC-FI was constructed using baseline data. The SLICC-FI comprises 48 health deficits, including items related to organ damage, disease activity, comorbidities, and functional status. Content, construct, and criterion validity of the SLICC-FI were assessed. Multivariable Cox regression was used to estimate the association between baseline SLICC-FI values and mortality risk, adjusting for demographic and clinical factors.RESULTS: In the baseline data set of 1,683 patients with SLE, 89{\%} were female, the mean ± SD age was 35.7 ± 13.4 years, and the mean ± SD disease duration was 18.8 ± 15.7 months. At baseline, the mean ± SD SLICC-FI score was 0.17 ± 0.08 (range 0-0.51). Baseline SLICC-FI values exhibited the expected measurement properties and were weakly correlated with baseline SDI scores (r = 0.26, P < 0.0001). Higher baseline SLICC-FI values (per 0.05 increment) were associated with increased mortality risk (hazard ratio 1.59, 95{\%} confidence interval 1.35-1.87), after adjusting for age, sex, steroid use, ethnicity/region, and baseline SDI scores.CONCLUSION: The SLICC-FI demonstrates internal validity as a health measure in SLE and might be used to predict future mortality risk. The SLICC-FI is potentially valuable for quantifying vulnerability among patients with SLE, and adds to existing prognostic scores.",
author = "Alexandra Legge and Susan Kirkland and Kenneth Rockwood and Pantelis Andreou and Sang-Cheol Bae and Caroline Gordon and Juanita Romero-Diaz and Jorge Sanchez-Guerrero and Wallace, {Daniel J} and Sasha Bernatsky and Clarke, {Ann E} and Merrill, {Joan T} and Ginzler, {Ellen M} and Paul Fortin and Gladman, {Dafna D} and Urowitz, {Murray B} and Bruce, {Ian N} and Isenberg, {David A} and Anisur Rahman and Alarc{\'o}n, {Graciela S} and Michelle Petri and Khamashta, {Munther A} and Dooley, {M A} and Rosalind Ramsey-Goldman and Susan Manzi and Kristjan Steinsson and Zoma, {Asad A} and Cynthia Aranow and Meggan Mackay and Guillermo Ruiz-Irastorza and Lim, {S Sam} and Murat Inanc and {van Vollenhoven}, {Ronald F} and Andreas Jonsen and Ola Nived and Manuel Ramos-Casals and Kamen, {Diane L} and Kalunian, {Kenneth C} and Soren Jacobsen and Peschken, {Christine A} and Anca Askanase and Hanly, {John G}",
note = "{\circledC} 2019, American College of Rheumatology.",
year = "2019",
month = "8",
doi = "10.1002/art.40859",
language = "English",
volume = "71",
pages = "1297--1307",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus

AU - Legge, Alexandra

AU - Kirkland, Susan

AU - Rockwood, Kenneth

AU - Andreou, Pantelis

AU - Bae, Sang-Cheol

AU - Gordon, Caroline

AU - Romero-Diaz, Juanita

AU - Sanchez-Guerrero, Jorge

AU - Wallace, Daniel J

AU - Bernatsky, Sasha

AU - Clarke, Ann E

AU - Merrill, Joan T

AU - Ginzler, Ellen M

AU - Fortin, Paul

AU - Gladman, Dafna D

AU - Urowitz, Murray B

AU - Bruce, Ian N

AU - Isenberg, David A

AU - Rahman, Anisur

AU - Alarcón, Graciela S

AU - Petri, Michelle

AU - Khamashta, Munther A

AU - Dooley, M A

AU - Ramsey-Goldman, Rosalind

AU - Manzi, Susan

AU - Steinsson, Kristjan

AU - Zoma, Asad A

AU - Aranow, Cynthia

AU - Mackay, Meggan

AU - Ruiz-Irastorza, Guillermo

AU - Lim, S Sam

AU - Inanc, Murat

AU - van Vollenhoven, Ronald F

AU - Jonsen, Andreas

AU - Nived, Ola

AU - Ramos-Casals, Manuel

AU - Kamen, Diane L

AU - Kalunian, Kenneth C

AU - Jacobsen, Soren

AU - Peschken, Christine A

AU - Askanase, Anca

AU - Hanly, John G

N1 - © 2019, American College of Rheumatology.

PY - 2019/8

Y1 - 2019/8

N2 - OBJECTIVE: To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in systemic lupus erythematosus (SLE).METHODS: For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36] scores) were assessed. The SLICC-FI was constructed using baseline data. The SLICC-FI comprises 48 health deficits, including items related to organ damage, disease activity, comorbidities, and functional status. Content, construct, and criterion validity of the SLICC-FI were assessed. Multivariable Cox regression was used to estimate the association between baseline SLICC-FI values and mortality risk, adjusting for demographic and clinical factors.RESULTS: In the baseline data set of 1,683 patients with SLE, 89% were female, the mean ± SD age was 35.7 ± 13.4 years, and the mean ± SD disease duration was 18.8 ± 15.7 months. At baseline, the mean ± SD SLICC-FI score was 0.17 ± 0.08 (range 0-0.51). Baseline SLICC-FI values exhibited the expected measurement properties and were weakly correlated with baseline SDI scores (r = 0.26, P < 0.0001). Higher baseline SLICC-FI values (per 0.05 increment) were associated with increased mortality risk (hazard ratio 1.59, 95% confidence interval 1.35-1.87), after adjusting for age, sex, steroid use, ethnicity/region, and baseline SDI scores.CONCLUSION: The SLICC-FI demonstrates internal validity as a health measure in SLE and might be used to predict future mortality risk. The SLICC-FI is potentially valuable for quantifying vulnerability among patients with SLE, and adds to existing prognostic scores.

AB - OBJECTIVE: To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in systemic lupus erythematosus (SLE).METHODS: For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36] scores) were assessed. The SLICC-FI was constructed using baseline data. The SLICC-FI comprises 48 health deficits, including items related to organ damage, disease activity, comorbidities, and functional status. Content, construct, and criterion validity of the SLICC-FI were assessed. Multivariable Cox regression was used to estimate the association between baseline SLICC-FI values and mortality risk, adjusting for demographic and clinical factors.RESULTS: In the baseline data set of 1,683 patients with SLE, 89% were female, the mean ± SD age was 35.7 ± 13.4 years, and the mean ± SD disease duration was 18.8 ± 15.7 months. At baseline, the mean ± SD SLICC-FI score was 0.17 ± 0.08 (range 0-0.51). Baseline SLICC-FI values exhibited the expected measurement properties and were weakly correlated with baseline SDI scores (r = 0.26, P < 0.0001). Higher baseline SLICC-FI values (per 0.05 increment) were associated with increased mortality risk (hazard ratio 1.59, 95% confidence interval 1.35-1.87), after adjusting for age, sex, steroid use, ethnicity/region, and baseline SDI scores.CONCLUSION: The SLICC-FI demonstrates internal validity as a health measure in SLE and might be used to predict future mortality risk. The SLICC-FI is potentially valuable for quantifying vulnerability among patients with SLE, and adds to existing prognostic scores.

U2 - 10.1002/art.40859

DO - 10.1002/art.40859

M3 - Journal article

VL - 71

SP - 1297

EP - 1307

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 8

ER -

ID: 58902611