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Evaluating combinations of diagnostic tests to discriminate different dementia types

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Bruun, M, Rhodius-Meester, HFM, Koikkalainen, J, Baroni, M, Gjerum, L, Lemstra, AW, Barkhof, F, Remes, AM, Urhemaa, T, Tolonen, A, Rueckert, D, van Gils, M, Frederiksen, KS, Waldemar, G, Scheltens, P, Mecocci, P, Soininen, H, Lötjönen, J, Hasselbalch, SG & van der Flier, WM 2018, 'Evaluating combinations of diagnostic tests to discriminate different dementia types' Alzheimer's & dementia (Amsterdam, Netherlands), vol. 10, pp. 509-518. https://doi.org/10.1016/j.dadm.2018.07.003

APA

CBE

Bruun M, Rhodius-Meester HFM, Koikkalainen J, Baroni M, Gjerum L, Lemstra AW, Barkhof F, Remes AM, Urhemaa T, Tolonen A, Rueckert D, van Gils M, Frederiksen KS, Waldemar G, Scheltens P, Mecocci P, Soininen H, Lötjönen J, Hasselbalch SG, van der Flier WM. 2018. Evaluating combinations of diagnostic tests to discriminate different dementia types. Alzheimer's & dementia (Amsterdam, Netherlands). 10:509-518. https://doi.org/10.1016/j.dadm.2018.07.003

MLA

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Author

Bruun, Marie ; Rhodius-Meester, Hanneke F M ; Koikkalainen, Juha ; Baroni, Marta ; Gjerum, Le ; Lemstra, Afina W ; Barkhof, Frederik ; Remes, Anne M ; Urhemaa, Timo ; Tolonen, Antti ; Rueckert, Daniel ; van Gils, Mark ; Frederiksen, Kristian S ; Waldemar, Gunhild ; Scheltens, Philip ; Mecocci, Patrizia ; Soininen, Hilkka ; Lötjönen, Jyrki ; Hasselbalch, Steen G ; van der Flier, Wiesje M. / Evaluating combinations of diagnostic tests to discriminate different dementia types. In: Alzheimer's & dementia (Amsterdam, Netherlands). 2018 ; Vol. 10. pp. 509-518.

Bibtex

@article{c92be1e72f67493abbe5596a35806a0c,
title = "Evaluating combinations of diagnostic tests to discriminate different dementia types",
abstract = "Introduction: We studied, using a data-driven approach, how different combinations of diagnostic tests contribute to the differential diagnosis of dementia.Methods: In this multicenter study, we included 356 patients with Alzheimer's disease, 87 frontotemporal dementia, 61 dementia with Lewy bodies, 38 vascular dementia, and 302 controls. We used a classifier to assess accuracy for individual performance and combinations of cognitive tests, cerebrospinal fluid biomarkers, and automated magnetic resonance imaging features for pairwise differentiation between dementia types.Results: Cognitive tests had good performance in separating any type of dementia from controls. Cerebrospinal fluid optimally contributed to identifying Alzheimer's disease, whereas magnetic resonance imaging features aided in separating vascular dementia, dementia with Lewy bodies, and frontotemporal dementia. Combining diagnostic tests increased the accuracy, with balanced accuracies ranging from 78{\%} to 97{\%}.Discussion: Different diagnostic tests have their distinct roles in differential diagnostics of dementias. Our results indicate that combining different diagnostic tests may increase the accuracy further.",
author = "Marie Bruun and Rhodius-Meester, {Hanneke F M} and Juha Koikkalainen and Marta Baroni and Le Gjerum and Lemstra, {Afina W} and Frederik Barkhof and Remes, {Anne M} and Timo Urhemaa and Antti Tolonen and Daniel Rueckert and {van Gils}, Mark and Frederiksen, {Kristian S} and Gunhild Waldemar and Philip Scheltens and Patrizia Mecocci and Hilkka Soininen and Jyrki L{\"o}tj{\"o}nen and Hasselbalch, {Steen G} and {van der Flier}, {Wiesje M}",
year = "2018",
doi = "10.1016/j.dadm.2018.07.003",
language = "English",
volume = "10",
pages = "509--518",
journal = "Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier Inc",

}

RIS

TY - JOUR

T1 - Evaluating combinations of diagnostic tests to discriminate different dementia types

AU - Bruun, Marie

AU - Rhodius-Meester, Hanneke F M

AU - Koikkalainen, Juha

AU - Baroni, Marta

AU - Gjerum, Le

AU - Lemstra, Afina W

AU - Barkhof, Frederik

AU - Remes, Anne M

AU - Urhemaa, Timo

AU - Tolonen, Antti

AU - Rueckert, Daniel

AU - van Gils, Mark

AU - Frederiksen, Kristian S

AU - Waldemar, Gunhild

AU - Scheltens, Philip

AU - Mecocci, Patrizia

AU - Soininen, Hilkka

AU - Lötjönen, Jyrki

AU - Hasselbalch, Steen G

AU - van der Flier, Wiesje M

PY - 2018

Y1 - 2018

N2 - Introduction: We studied, using a data-driven approach, how different combinations of diagnostic tests contribute to the differential diagnosis of dementia.Methods: In this multicenter study, we included 356 patients with Alzheimer's disease, 87 frontotemporal dementia, 61 dementia with Lewy bodies, 38 vascular dementia, and 302 controls. We used a classifier to assess accuracy for individual performance and combinations of cognitive tests, cerebrospinal fluid biomarkers, and automated magnetic resonance imaging features for pairwise differentiation between dementia types.Results: Cognitive tests had good performance in separating any type of dementia from controls. Cerebrospinal fluid optimally contributed to identifying Alzheimer's disease, whereas magnetic resonance imaging features aided in separating vascular dementia, dementia with Lewy bodies, and frontotemporal dementia. Combining diagnostic tests increased the accuracy, with balanced accuracies ranging from 78% to 97%.Discussion: Different diagnostic tests have their distinct roles in differential diagnostics of dementias. Our results indicate that combining different diagnostic tests may increase the accuracy further.

AB - Introduction: We studied, using a data-driven approach, how different combinations of diagnostic tests contribute to the differential diagnosis of dementia.Methods: In this multicenter study, we included 356 patients with Alzheimer's disease, 87 frontotemporal dementia, 61 dementia with Lewy bodies, 38 vascular dementia, and 302 controls. We used a classifier to assess accuracy for individual performance and combinations of cognitive tests, cerebrospinal fluid biomarkers, and automated magnetic resonance imaging features for pairwise differentiation between dementia types.Results: Cognitive tests had good performance in separating any type of dementia from controls. Cerebrospinal fluid optimally contributed to identifying Alzheimer's disease, whereas magnetic resonance imaging features aided in separating vascular dementia, dementia with Lewy bodies, and frontotemporal dementia. Combining diagnostic tests increased the accuracy, with balanced accuracies ranging from 78% to 97%.Discussion: Different diagnostic tests have their distinct roles in differential diagnostics of dementias. Our results indicate that combining different diagnostic tests may increase the accuracy further.

U2 - 10.1016/j.dadm.2018.07.003

DO - 10.1016/j.dadm.2018.07.003

M3 - Journal article

VL - 10

SP - 509

EP - 518

JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

SN - 2352-8729

ER -

ID: 55491736