EUS-guided biopsies versus surgical specimens for establishing patient-derived pancreatic cancer organoids: A systematic review and meta-analysis

Simon Ezban Grützmeier; Hafsa Mahad Mahamud Sodal; Bojan Kovacevic; Peter Vilmann; John Gásdal Karstensen; Pia Klausen

doi:10.1016/j.gie.2024.04.012

EUS-guided biopsies versus surgical specimens for establishing patient-derived pancreatic cancer organoids: A systematic review and meta-analysis

Simon Ezban Grützmeier^*, Hafsa Mahad Mahamud Sodal, Bojan Kovacevic, Peter Vilmann, John Gásdal Karstensen, Pia Klausen

^*Corresponding author for this work

7 Citations (Scopus)

Abstract

BACKGROUND AND AIMS: Patient-derived tumor organoids (PDTOs) are a promising new disease model in pancreatic cancer for use in personalized medicine. However, the overall success rate (SR) of establishing these cultures from EUS-guided biopsies is unknown.

METHODS: We searched relevant database publications reporting SRs of PDTO establishment from pancreatic cancer. The primary outcome was SR stratified on tissue acquisition method (EUS-guided biopsies, percutaneous biopsies, and surgical specimens).

RESULTS: Twenty-four studies were identified that included 1053 attempts at establishing PDTOs. Overall SR was 63% (95% confidence interval [CI], 54%-72%). Pooled SRs of PDTO establishment from EUS-guided biopsies, percutaneous biopsies, and surgical specimens were 60% (95% CI, 43%-76%), 36% (95% CI, 14%-61%), and 62% (95% CI, 48%-75%), respectively, and did not differ significantly (P = .1975).

CONCLUSION: The SR of PDTO establishment from EUS-guided biopsies is comparable to that from surgical specimens. Both techniques are suitable for tissue acquisition for PDTOs in clinical and research settings. (PROSPERO registration number: CRD42023425121.).

Original language	English
Journal	Gastrointestinal Endoscopy
Volume	100
Issue number	4
Pages (from-to)	750-755
Number of pages	6
ISSN	0016-5107
DOIs	https://doi.org/10.1016/j.gie.2024.04.012
Publication status	Published - Oct 2024

Keywords

Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods
Endosonography/methods
Humans
Image-Guided Biopsy/methods
Organoids/pathology
Pancreatic Neoplasms/pathology
Ultrasonography, Interventional/methods

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10.1016/j.gie.2024.04.012Licence: CC BY

Cite this

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title = "EUS-guided biopsies versus surgical specimens for establishing patient-derived pancreatic cancer organoids: A systematic review and meta-analysis",

abstract = "BACKGROUND AND AIMS: Patient-derived tumor organoids (PDTOs) are a promising new disease model in pancreatic cancer for use in personalized medicine. However, the overall success rate (SR) of establishing these cultures from EUS-guided biopsies is unknown.METHODS: We searched relevant database publications reporting SRs of PDTO establishment from pancreatic cancer. The primary outcome was SR stratified on tissue acquisition method (EUS-guided biopsies, percutaneous biopsies, and surgical specimens).RESULTS: Twenty-four studies were identified that included 1053 attempts at establishing PDTOs. Overall SR was 63\% (95\% confidence interval [CI], 54\%-72\%). Pooled SRs of PDTO establishment from EUS-guided biopsies, percutaneous biopsies, and surgical specimens were 60\% (95\% CI, 43\%-76\%), 36\% (95\% CI, 14\%-61\%), and 62\% (95\% CI, 48\%-75\%), respectively, and did not differ significantly (P = .1975).CONCLUSION: The SR of PDTO establishment from EUS-guided biopsies is comparable to that from surgical specimens. Both techniques are suitable for tissue acquisition for PDTOs in clinical and research settings. (PROSPERO registration number: CRD42023425121.).",

keywords = "Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods, Endosonography/methods, Humans, Image-Guided Biopsy/methods, Organoids/pathology, Pancreatic Neoplasms/pathology, Ultrasonography, Interventional/methods",

author = "Gr{\"u}tzmeier, \{Simon Ezban\} and Sodal, \{Hafsa Mahad Mahamud\} and Bojan Kovacevic and Peter Vilmann and Karstensen, \{John G{\'a}sdal\} and Pia Klausen",

year = "2024",

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doi = "10.1016/j.gie.2024.04.012",

language = "English",

volume = "100",

pages = "750--755",

journal = "Gastrointestinal Endoscopy",

issn = "0016-5107",

publisher = "Elsevier Inc.",

number = "4",

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TY - JOUR

T1 - EUS-guided biopsies versus surgical specimens for establishing patient-derived pancreatic cancer organoids

T2 - A systematic review and meta-analysis

AU - Grützmeier, Simon Ezban

AU - Sodal, Hafsa Mahad Mahamud

AU - Kovacevic, Bojan

AU - Vilmann, Peter

AU - Karstensen, John Gásdal

AU - Klausen, Pia

PY - 2024/10

Y1 - 2024/10

N2 - BACKGROUND AND AIMS: Patient-derived tumor organoids (PDTOs) are a promising new disease model in pancreatic cancer for use in personalized medicine. However, the overall success rate (SR) of establishing these cultures from EUS-guided biopsies is unknown.METHODS: We searched relevant database publications reporting SRs of PDTO establishment from pancreatic cancer. The primary outcome was SR stratified on tissue acquisition method (EUS-guided biopsies, percutaneous biopsies, and surgical specimens).RESULTS: Twenty-four studies were identified that included 1053 attempts at establishing PDTOs. Overall SR was 63% (95% confidence interval [CI], 54%-72%). Pooled SRs of PDTO establishment from EUS-guided biopsies, percutaneous biopsies, and surgical specimens were 60% (95% CI, 43%-76%), 36% (95% CI, 14%-61%), and 62% (95% CI, 48%-75%), respectively, and did not differ significantly (P = .1975).CONCLUSION: The SR of PDTO establishment from EUS-guided biopsies is comparable to that from surgical specimens. Both techniques are suitable for tissue acquisition for PDTOs in clinical and research settings. (PROSPERO registration number: CRD42023425121.).

AB - BACKGROUND AND AIMS: Patient-derived tumor organoids (PDTOs) are a promising new disease model in pancreatic cancer for use in personalized medicine. However, the overall success rate (SR) of establishing these cultures from EUS-guided biopsies is unknown.METHODS: We searched relevant database publications reporting SRs of PDTO establishment from pancreatic cancer. The primary outcome was SR stratified on tissue acquisition method (EUS-guided biopsies, percutaneous biopsies, and surgical specimens).RESULTS: Twenty-four studies were identified that included 1053 attempts at establishing PDTOs. Overall SR was 63% (95% confidence interval [CI], 54%-72%). Pooled SRs of PDTO establishment from EUS-guided biopsies, percutaneous biopsies, and surgical specimens were 60% (95% CI, 43%-76%), 36% (95% CI, 14%-61%), and 62% (95% CI, 48%-75%), respectively, and did not differ significantly (P = .1975).CONCLUSION: The SR of PDTO establishment from EUS-guided biopsies is comparable to that from surgical specimens. Both techniques are suitable for tissue acquisition for PDTOs in clinical and research settings. (PROSPERO registration number: CRD42023425121.).

KW - Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods

KW - Endosonography/methods

KW - Humans

KW - Image-Guided Biopsy/methods

KW - Organoids/pathology

KW - Pancreatic Neoplasms/pathology

KW - Ultrasonography, Interventional/methods

UR - https://www.scopus.com/pages/publications/85199684618

U2 - 10.1016/j.gie.2024.04.012

DO - 10.1016/j.gie.2024.04.012

M3 - Review

C2 - 38593932

SN - 0016-5107

VL - 100

SP - 750

EP - 755

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

IS - 4

ER -

EUS-guided biopsies versus surgical specimens for establishing patient-derived pancreatic cancer organoids: A systematic review and meta-analysis

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