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European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents

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@article{467192d7020f4e32b2f18f19affefb50,
title = "European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents",
abstract = "Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological vulnerability to the development of tics and associated behaviours. However, the existing evidence for this relies primarily on small prospective or larger retrospective population-based studies, and is therefore still inconclusive. This article describes the design and methodology of the EMTICS study, a longitudinal observational European multicentre study involving 16 clinical centres, with the following objectives: (1) to investigate the association of environmental factors (GAS exposure and psychosocial stress, primarily) with the onset and course of tics and/or obsessive-compulsive symptoms through the prospective observation of at-risk individuals (ONSET cohort: 260 children aged 3-10 years who are tic-free at study entry and have a first-degree relative with a chronic tic disorder) and affected individuals (COURSE cohort: 715 youth aged 3-16 years with a tic disorder); (2) to characterise the immune response to microbial antigens and the host's immune response regulation in association with onset and exacerbations of tics; (3) to increase knowledge of the human gene pathways influencing the pathogenesis of tic disorders; and (4) to develop prediction models for the risk of onset and exacerbations of tic disorders. The EMTICS study is, to our knowledge, the largest prospective cohort assessment of the contribution of different genetic and environmental factors to the risk of developing tics in putatively predisposed individuals and to the risk of exacerbating tics in young individuals with chronic tic disorders.",
author = "Anette Schrag and Davide Martino and Alan Apter and Juliane Ball and Erika Bartolini and Noa Benaroya-Milshtein and Maura Buttiglione and Francesco Cardona and Roberta Creti and Androulla Efstratiou and Maria Gariup and Marianthi Georgitsi and Tammy Hedderly and Isobel Heyman and Immaculada Margarit and Pablo Mir and Natalie Moll and Astrid Morer and Norbert M{\"u}ller and Kirsten M{\"u}ller-Vahl and Alexander M{\"u}nchau and Graziella Orefici and Plessen, {Kerstin J} and Cesare Porcelli and Peristera Paschou and Renata Rizzo and Veit Roessner and Schwarz, {Markus J} and Tamar Steinberg and {Tagwerker Gloor}, Friederike and Zsanett Tarnok and Susanne Walitza and Andrea Dietrich and Hoekstra, {Pieter J} and {EMTICS Collaborative Group} and Julie Hagstr{\o}m",
year = "2019",
month = "1",
doi = "10.1007/s00787-018-1190-4",
language = "English",
volume = "28",
pages = "91--109",
journal = "European Child and Adolescent Psychiatry",
issn = "1018-8827",
publisher = "Dr. Dietrich/Steinkopff Verlag",

}

RIS

TY - JOUR

T1 - European Multicentre Tics in Children Studies (EMTICS)

T2 - protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents

AU - Schrag, Anette

AU - Martino, Davide

AU - Apter, Alan

AU - Ball, Juliane

AU - Bartolini, Erika

AU - Benaroya-Milshtein, Noa

AU - Buttiglione, Maura

AU - Cardona, Francesco

AU - Creti, Roberta

AU - Efstratiou, Androulla

AU - Gariup, Maria

AU - Georgitsi, Marianthi

AU - Hedderly, Tammy

AU - Heyman, Isobel

AU - Margarit, Immaculada

AU - Mir, Pablo

AU - Moll, Natalie

AU - Morer, Astrid

AU - Müller, Norbert

AU - Müller-Vahl, Kirsten

AU - Münchau, Alexander

AU - Orefici, Graziella

AU - Plessen, Kerstin J

AU - Porcelli, Cesare

AU - Paschou, Peristera

AU - Rizzo, Renata

AU - Roessner, Veit

AU - Schwarz, Markus J

AU - Steinberg, Tamar

AU - Tagwerker Gloor, Friederike

AU - Tarnok, Zsanett

AU - Walitza, Susanne

AU - Dietrich, Andrea

AU - Hoekstra, Pieter J

AU - EMTICS Collaborative Group

A2 - Hagstrøm, Julie

PY - 2019/1

Y1 - 2019/1

N2 - Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological vulnerability to the development of tics and associated behaviours. However, the existing evidence for this relies primarily on small prospective or larger retrospective population-based studies, and is therefore still inconclusive. This article describes the design and methodology of the EMTICS study, a longitudinal observational European multicentre study involving 16 clinical centres, with the following objectives: (1) to investigate the association of environmental factors (GAS exposure and psychosocial stress, primarily) with the onset and course of tics and/or obsessive-compulsive symptoms through the prospective observation of at-risk individuals (ONSET cohort: 260 children aged 3-10 years who are tic-free at study entry and have a first-degree relative with a chronic tic disorder) and affected individuals (COURSE cohort: 715 youth aged 3-16 years with a tic disorder); (2) to characterise the immune response to microbial antigens and the host's immune response regulation in association with onset and exacerbations of tics; (3) to increase knowledge of the human gene pathways influencing the pathogenesis of tic disorders; and (4) to develop prediction models for the risk of onset and exacerbations of tic disorders. The EMTICS study is, to our knowledge, the largest prospective cohort assessment of the contribution of different genetic and environmental factors to the risk of developing tics in putatively predisposed individuals and to the risk of exacerbating tics in young individuals with chronic tic disorders.

AB - Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological vulnerability to the development of tics and associated behaviours. However, the existing evidence for this relies primarily on small prospective or larger retrospective population-based studies, and is therefore still inconclusive. This article describes the design and methodology of the EMTICS study, a longitudinal observational European multicentre study involving 16 clinical centres, with the following objectives: (1) to investigate the association of environmental factors (GAS exposure and psychosocial stress, primarily) with the onset and course of tics and/or obsessive-compulsive symptoms through the prospective observation of at-risk individuals (ONSET cohort: 260 children aged 3-10 years who are tic-free at study entry and have a first-degree relative with a chronic tic disorder) and affected individuals (COURSE cohort: 715 youth aged 3-16 years with a tic disorder); (2) to characterise the immune response to microbial antigens and the host's immune response regulation in association with onset and exacerbations of tics; (3) to increase knowledge of the human gene pathways influencing the pathogenesis of tic disorders; and (4) to develop prediction models for the risk of onset and exacerbations of tic disorders. The EMTICS study is, to our knowledge, the largest prospective cohort assessment of the contribution of different genetic and environmental factors to the risk of developing tics in putatively predisposed individuals and to the risk of exacerbating tics in young individuals with chronic tic disorders.

U2 - 10.1007/s00787-018-1190-4

DO - 10.1007/s00787-018-1190-4

M3 - Journal article

VL - 28

SP - 91

EP - 109

JO - European Child and Adolescent Psychiatry

JF - European Child and Adolescent Psychiatry

SN - 1018-8827

ER -

ID: 54861550