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E-pub ahead of print

European guidelines on microscopic colitis: United European Gastroenterology (UEG) and European Microscopic Colitis Group (EMCG) statements and recommendations

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  2. Is revision of cutoff values needed when using CD3 immunohistochemical staining in histopathologic diagnosis of lymphocytic colitis?

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  3. Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Stephan Miehlke
  • Danila Guagnozzi
  • Yamile Zabana
  • Gian E Tontini
  • Anne-Marie Kanstrup Fiehn
  • Signe Wildt
  • Johan Bohr
  • Ole Bonderup
  • Gerd Bouma
  • Mauro D'Amato
  • Peter Johan Heiberg Engel
  • Fernando Fernandez-Banares
  • Gilles Macaigne
  • Henrik Hjortswang
  • Elisabeth Hultgren-Hörnquist
  • Anastasios Koulaouzidis
  • Jouzas Kupcinskas
  • Stefania Landolfi
  • Giovanni Latella
  • Alfredo Lucendo
  • Ivan Lyutakov
  • Ahmed Madisch
  • Fernando Magro
  • Wojciech Marlicz
  • Emese Mihaly
  • Lars Kristian Munck
  • Ann-Elisabeth Ostvik
  • Árpád V Patai
  • Plamen Penchev
  • Karolina Skonieczna-Żydecka
  • Bas Verhaegh
  • Andreas Münch
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INTRODUCTION: Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, non-bloody diarrhoea and distinct histological abnormalities, which identify three histological subtypes, the collagenous colitis, the lymphocytic colitis and the incomplete microscopic colitis. With ongoing uncertainties and new developments in the clinical management of microscopic colitis, there is a need for evidence-based guidelines to improve the medical care of patients suffering from this disorder.

METHODS: Guidelines were developed by members from the European Microscopic Colitis Group and United European Gastroenterology in accordance with the Appraisal of Guidelines for Research and Evaluation II instrument. Following a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation methodology was used to assess the certainty of the evidence. Statements and recommendations were developed by working groups consisting of gastroenterologists, pathologists and basic scientists, and voted upon using the Delphi method.

RESULTS: These guidelines provide information on epidemiology and risk factors of microscopic colitis, as well as evidence-based statements and recommendations on diagnostic criteria and treatment options, including oral budesonide, bile acid binders, immunomodulators and biologics. Recommendations on the clinical management of microscopic colitis are provided based on evidence, expert opinion and best clinical practice.

CONCLUSION: These guidelines may support clinicians worldwide to improve the clinical management of patients with microscopic colitis.

Original languageEnglish
JournalUnited European Gastroenterology Journal
Pages (from-to)2050640620951905
Publication statusE-pub ahead of print - 20 Aug 2020

    Research areas

  • budesonide, diarrhoea, inflammatory bowel disease, Microscopic colitis

ID: 60920080