Et tilfælde af toksisk encefaloneuropati under behandling med nimorazol

Shanga Hassan Qadir; Ruta Jakubauskaite; Emilie Lund Laursen

doi:10.61409/V12240878

Et tilfælde af toksisk encefaloneuropati under behandling med nimorazol

Translated title of the contribution: A case of toxic encephaloneuropathy during treatment with nimorazole

Shanga Hassan Qadir^*, Ruta Jakubauskaite, Emilie Lund Laursen

^*Corresponding author for this work

Abstract

5-nitroimidazoles (5-NI) are pharmacologically diverse drugs used mainly for anaerobic and parasitic infections. Metronidazole is the most widely used 5-NI and has rare neurotoxic effects, including cerebellar and brainstem dysfunction, encephalopathy, and seizures. Other (5-NI) have been studied as hypoxic cell radiosensitizers but are limited by dose-dependent side effects. Nimorazole is in use in Denmark for head-and-neck cancer and is considered safe. No cases of nimorazole-induced neurotoxicity like Metronidazole encephalopathy have been published. In this case, we report a patient who developed toxic encephaloneuropathy during nimorazole radiosensitisation.

Translated title of the contribution	A case of toxic encephaloneuropathy during treatment with nimorazole
Original language	Danish
Article number	V12240878
Journal	Ugeskrift for Laeger
Volume	187
Issue number	29
Pages (from-to)	1-3
Number of pages	3
ISSN	0041-5782
DOIs	https://doi.org/10.61409/V12240878
Publication status	Published - 14 Jul 2025

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10.61409/V12240878Licence: CC BY-NC-ND

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title = "Et tilf{\ae}lde af toksisk encefaloneuropati under behandling med nimorazol",

abstract = "5-nitroimidazoles (5-NI) are pharmacologically diverse drugs used mainly for anaerobic and parasitic infections. Metronidazole is the most widely used 5-NI and has rare neurotoxic effects, including cerebellar and brainstem dysfunction, encephalopathy, and seizures. Other (5-NI) have been studied as hypoxic cell radiosensitizers but are limited by dose-dependent side effects. Nimorazole is in use in Denmark for head-and-neck cancer and is considered safe. No cases of nimorazole-induced neurotoxicity like Metronidazole encephalopathy have been published. In this case, we report a patient who developed toxic encephaloneuropathy during nimorazole radiosensitisation.",

keywords = "Humans, Metronidazole/adverse effects, Male, Neurotoxicity Syndromes/etiology, Radiation-Sensitizing Agents/adverse effects, Middle Aged",

author = "Qadir, \{Shanga Hassan\} and Ruta Jakubauskaite and Laursen, \{Emilie Lund\}",

note = "Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.",

year = "2025",

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doi = "10.61409/V12240878",

language = "Dansk",

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T1 - Et tilfælde af toksisk encefaloneuropati under behandling med nimorazol

AU - Qadir, Shanga Hassan

AU - Jakubauskaite, Ruta

AU - Laursen, Emilie Lund

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2025/7/14

Y1 - 2025/7/14

N2 - 5-nitroimidazoles (5-NI) are pharmacologically diverse drugs used mainly for anaerobic and parasitic infections. Metronidazole is the most widely used 5-NI and has rare neurotoxic effects, including cerebellar and brainstem dysfunction, encephalopathy, and seizures. Other (5-NI) have been studied as hypoxic cell radiosensitizers but are limited by dose-dependent side effects. Nimorazole is in use in Denmark for head-and-neck cancer and is considered safe. No cases of nimorazole-induced neurotoxicity like Metronidazole encephalopathy have been published. In this case, we report a patient who developed toxic encephaloneuropathy during nimorazole radiosensitisation.

AB - 5-nitroimidazoles (5-NI) are pharmacologically diverse drugs used mainly for anaerobic and parasitic infections. Metronidazole is the most widely used 5-NI and has rare neurotoxic effects, including cerebellar and brainstem dysfunction, encephalopathy, and seizures. Other (5-NI) have been studied as hypoxic cell radiosensitizers but are limited by dose-dependent side effects. Nimorazole is in use in Denmark for head-and-neck cancer and is considered safe. No cases of nimorazole-induced neurotoxicity like Metronidazole encephalopathy have been published. In this case, we report a patient who developed toxic encephaloneuropathy during nimorazole radiosensitisation.

KW - Humans

KW - Metronidazole/adverse effects

KW - Male

KW - Neurotoxicity Syndromes/etiology

KW - Radiation-Sensitizing Agents/adverse effects

KW - Middle Aged

UR - https://www.scopus.com/pages/publications/105012791028

U2 - 10.61409/V12240878

DO - 10.61409/V12240878

M3 - Tidsskriftartikel

C2 - 40746124

SN - 0041-5782

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JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 29

M1 - V12240878

ER -

Et tilfælde af toksisk encefaloneuropati under behandling med nimorazol

Abstract

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