Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study

Henrik Christian Bidstrup Leffers; David Westergaard; Saedis Saevarsdottir; Ingileif Jonsdottir; Ole Birger Pedersen; Anne Troldborg; Anne Voss; Salome Kristensen; Jesper Lindhardsen; Prabhat Kumar; Asta Linauskas; Lars Juul; Niels Steen Krogh; Bent Deleuran; Lene Dreyer; Michael Schwinn; Lise Wegner Thørner; Lotte Hindhede; Christian Erikstrup; Henrik Ullum; Søren Brunak; Kari Stefansson; Karina Banasik; Søren Jacobsen; DBDS Genomic Consortium

doi:10.1016/j.jbspin.2022.105357

Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study

Henrik Christian Bidstrup Leffers^*, David Westergaard, Saedis Saevarsdottir, Ingileif Jonsdottir, Ole Birger Pedersen, Anne Troldborg, Anne Voss, Salome Kristensen, Jesper Lindhardsen, Prabhat Kumar, Asta Linauskas, Lars Juul, Niels Steen Krogh, Bent Deleuran, Lene Dreyer, Michael Schwinn, Lise Wegner Thørner, Lotte Hindhede, Christian Erikstrup, Henrik UllumSøren Brunak, Kari Stefansson, Karina Banasik, Søren Jacobsen, DBDS Genomic Consortium

^*Corresponding author for this work

Original language	English
Article number	105357
Journal	Joint Bone Spine
Volume	89
Issue number	4
ISSN	1169-8446
DOIs	https://doi.org/10.1016/j.jbspin.2022.105357
Publication status	Published - Jul 2022

Keywords

CD11b Antigen/genetics
Case-Control Studies
Denmark/epidemiology
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Interferon Regulatory Factors/genetics
Lupus Erythematosus, Systemic/genetics
NADPH Oxidases
Polymorphism, Single Nucleotide
STAT4 Transcription Factor
beta Karyopherins
Systemic Lupus Erythematosus
GWAS
Genome wide association study
Clinical phenotype
SLE
Lupus Nephritis
Disease manifestations

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Leffers, H. C. B., Westergaard, D., Saevarsdottir, S., Jonsdottir, I., Pedersen, O. B., Troldborg, A., Voss, A., Kristensen, S., Lindhardsen, J., Kumar, P., Linauskas, A., Juul, L., Krogh, N. S., Deleuran, B., Dreyer, L., Schwinn, M., Thørner, L. W., Hindhede, L., Erikstrup, C., ... DBDS Genomic Consortium (2022). Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study. Joint Bone Spine, 89(4), [105357]. https://doi.org/10.1016/j.jbspin.2022.105357

Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations : A Danish genome-wide association study. / Leffers, Henrik Christian Bidstrup; Westergaard, David; Saevarsdottir, Saedis et al.

In: Joint Bone Spine, Vol. 89, No. 4, 105357, 07.2022.

Research output: Contribution to journal › Letter › peer-review

Leffers, HCB, Westergaard, D, Saevarsdottir, S, Jonsdottir, I, Pedersen, OB, Troldborg, A, Voss, A, Kristensen, S, Lindhardsen, J, Kumar, P, Linauskas, A, Juul, L, Krogh, NS, Deleuran, B, Dreyer, L, Schwinn, M, Thørner, LW, Hindhede, L, Erikstrup, C, Ullum, H, Brunak, S, Stefansson, K, Banasik, K, Jacobsen, S & DBDS Genomic Consortium 2022, 'Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study', Joint Bone Spine, vol. 89, no. 4, 105357. https://doi.org/10.1016/j.jbspin.2022.105357

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title = "Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study",

keywords = "CD11b Antigen/genetics, Case-Control Studies, Denmark/epidemiology, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Interferon Regulatory Factors/genetics, Lupus Erythematosus, Systemic/genetics, NADPH Oxidases, Polymorphism, Single Nucleotide, STAT4 Transcription Factor, beta Karyopherins, Systemic Lupus Erythematosus, GWAS, Genome wide association study, Clinical phenotype, SLE, Lupus Nephritis, Disease manifestations",

author = "Leffers, {Henrik Christian Bidstrup} and David Westergaard and Saedis Saevarsdottir and Ingileif Jonsdottir and Pedersen, {Ole Birger} and Anne Troldborg and Anne Voss and Salome Kristensen and Jesper Lindhardsen and Prabhat Kumar and Asta Linauskas and Lars Juul and Krogh, {Niels Steen} and Bent Deleuran and Lene Dreyer and Michael Schwinn and Th{\o}rner, {Lise Wegner} and Lotte Hindhede and Christian Erikstrup and Henrik Ullum and S{\o}ren Brunak and Kari Stefansson and Karina Banasik and S{\o}ren Jacobsen and {DBDS Genomic Consortium}",

year = "2022",

month = jul,

doi = "10.1016/j.jbspin.2022.105357",

language = "English",

volume = "89",

journal = "Joint Bone Spine",

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T2 - A Danish genome-wide association study

AU - Leffers, Henrik Christian Bidstrup

AU - Westergaard, David

AU - Saevarsdottir, Saedis

AU - Jonsdottir, Ingileif

AU - Pedersen, Ole Birger

AU - Troldborg, Anne

AU - Voss, Anne

AU - Kristensen, Salome

AU - Lindhardsen, Jesper

AU - Kumar, Prabhat

AU - Linauskas, Asta

AU - Juul, Lars

AU - Krogh, Niels Steen

AU - Deleuran, Bent

AU - Dreyer, Lene

AU - Schwinn, Michael

AU - Thørner, Lise Wegner

AU - Hindhede, Lotte

AU - Erikstrup, Christian

AU - Ullum, Henrik

AU - Brunak, Søren

AU - Stefansson, Kari

AU - Banasik, Karina

AU - Jacobsen, Søren

AU - DBDS Genomic Consortium

PY - 2022/7

Y1 - 2022/7

KW - CD11b Antigen/genetics

KW - Case-Control Studies

KW - Denmark/epidemiology

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Interferon Regulatory Factors/genetics

KW - Lupus Erythematosus, Systemic/genetics

KW - NADPH Oxidases

KW - Polymorphism, Single Nucleotide

KW - STAT4 Transcription Factor

KW - beta Karyopherins

KW - Systemic Lupus Erythematosus

KW - GWAS

KW - Genome wide association study

KW - Clinical phenotype

KW - SLE

KW - Lupus Nephritis

KW - Disease manifestations

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U2 - 10.1016/j.jbspin.2022.105357

DO - 10.1016/j.jbspin.2022.105357

M3 - Letter

C2 - 35167971

VL - 89

JO - Joint Bone Spine

JF - Joint Bone Spine

SN - 1169-8446

IS - 4

M1 - 105357

ER -

Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study

Keywords

Access to Document

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