Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Esophageal Endosonography for the Diagnosis of Intrapulmonary Tumors: A Systematic Review and Meta-Analysis

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Developing and Gathering Validity Evidence for a Simulation-Based Test of Competencies in Lung Ultrasound

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Development of and Gathering Validity Evidence for a Theoretical Test in Thoracic Ultrasound

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Endoscopic Ultrasound with Bronchoscope-Guided Fine Needle Aspiration for the Diagnosis of Paraesophageally Located Lung Lesions

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Ensuring Basic Competence in Thoracentesis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Maintaining Competence in Airway Management

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Using computerized assessment in simulated colonoscopy: a validation study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Ensuring Competency in Open Aortic Aneurysm Repair - Development and Validation of a New Assessment Tool

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Biopsy-based diagnosis in patients with paraesophageal intrapulmonary tumors suspected of lung cancer is crucial for adequate treatment planning.

OBJECTIVE: To evaluate the performance of transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the diagnosis of intrapulmonary tumors located near or adjacent to the esophagus.

METHODS: We performed a systematic review (PROSPERO, CRD42016033737) and searched MEDLINE, Embase, BIOSIS Previews, and Web of Science on September 22, 2016, without date or language restrictions. We included studies that evaluated the yield and/or sensitivity of EUS-FNA for diagnosing intrapulmonary tumors. Yield was defined as the number of patients in whom EUS-FNA made a biopsy-proven diagnosis (malignant or nonmalignant) relative to the total number of patients on whom EUS-FNA was performed. Sensitivity was defined as the number of patients in whom EUS-FNA made a biopsy-proven diagnosis of malignancy relative to the total number of patients in whom the tumor was found to be malignant. We performed a random-effects meta-analysis.

RESULTS: Of 3,320 search results, 11 studies were included. Ten had a high risk of bias. The total number of patients was 313; the proportion of patients with malignancy ranged from 87 to 100% across these studies. The average yield was 0.90 (95% CI 0.82-0.95) and the average sensitivity was 0.92 (0.83-0.96). In the subgroup of prospective studies (n = 3), the average yield was 0.80 (0.56-0.93) and the average sensitivity was 0.83 (0.58-0.95). EUS-FNA-induced complications were reported for 5/256 patients (2.0%) for whom this information was available.

CONCLUSIONS: Although the number of high-quality studies is limited, these findings suggest that EUS-FNA is safe and has a high yield for diagnosing intrapulmonary tumors.

Original languageEnglish
JournalRespiration; international review of thoracic diseases
Volume93
Issue number2
Pages (from-to)126-137
ISSN0025-7931
DOIs
Publication statusPublished - Jan 2017

ID: 49625808