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ESMO consensus conference recommendations on the management of metastatic melanoma: under the auspices of the ESMO Guidelines Committee

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Midkine-A potential therapeutic target in melanoma

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. Loss of Ambra1 promotes melanoma growth and invasion

    Research output: Contribution to journalJournal articleResearchpeer-review

  • U Keilholz
  • P A Ascierto
  • R Dummer
  • C Robert
  • P Lorigan
  • A van Akkooi
  • A Arance
  • C U Blank
  • V Chiarion Sileni
  • M Donia
  • M B Faries
  • C Gaudy-Marqueste
  • H Gogas
  • J J Grob
  • M Guckenberger
  • J Haanen
  • A J Hayes
  • C Hoeller
  • C Lebbé
  • I Lugowska
  • M Mandalà
  • I Márquez-Rodas
  • P Nathan
  • B Neyns
  • R Olofsson Bagge
  • S Puig
  • P Rutkowski
  • B Schilling
  • V K Sondak
  • H Tawbi
  • A Testori
  • O Michielin
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The European Society for Medical Oncology (ESMO) held a consensus conference on melanoma on 5-7 September 2019 in Amsterdam, The Netherlands. The conference included a multidisciplinary panel of 32 leading experts in the management of melanoma. The aim of the conference was to develop recommendations on topics that are not covered in detail in the current ESMO Clinical Practice Guideline and where available evidence is either limited or conflicting. The main topics identified for discussion were (i) the management of locoregional disease; (ii) targeted versus immunotherapies in the adjuvant setting; (iii) targeted versus immunotherapies for the first-line treatment of metastatic melanoma; (iv) when to stop immunotherapy or targeted therapy in the metastatic setting; and (v) systemic versus local treatment for brain metastases. The expert panel was divided into five working groups to each address questions relating to one of the five topics outlined above. Relevant scientific literature was reviewed in advance. Recommendations were developed by the working groups and then presented to the entire panel for further discussion and amendment before voting. This manuscript presents the results relating to the management of metastatic melanoma, including findings from the expert panel discussions, consensus recommendations and a summary of evidence supporting each recommendation. All participants approved the final manuscript.

Original languageEnglish
JournalAnnals of Oncology
Volume31
Issue number11
Pages (from-to)1435-1448
Number of pages14
ISSN0923-7534
DOIs
Publication statusPublished - Nov 2020

    Research areas

  • Consensus, Humans, Medical Oncology, Melanoma/therapy, Netherlands, consensus, targeted therapy, treatment, metastatic, immunotherapy, melanoma

ID: 61972265