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Erythropoietin as possible treatment of brain diseases

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  2. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

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Erythropoietin (EPO) is a hypoxia-inducible hormone best known for its role in erythropoiesis. However, EPO also has anti-inflammatory and tissue-protective characteristics in multiple organs as summarised in this review. In the brain, EPO is upregulated by hypoxia, regulates ventilation and plays a key role in neuroprotection and neuroplasticity. Systemically administered EPO crosses the blood-brain-barrier, enhances neuroplasticity and improves cognitive functions in several disorders of the brain. Given this evidence, a trial is being planned to investigate whether EPO can improve the physiologic and neurologic outcome of COVID-19.

Translated title of the contributionErythropoietin as possible treatment of brain diseases
Original languageDanish
JournalUgeskrift for Laeger
Volume182
Issue number44
ISSN0041-5782
Publication statusPublished - 26 Oct 2020

ID: 61340238