Abstract
It is now well-established that cancer is a genetic disease, although in most cases not inherited. A sporadic cancer develops when a somatic cell acquires specific growth advantages through successive accumulation of changes in cancer genes, including oncogenes, tumor suppressor genes and stability genes. Alterations of these genes lead to deregulation of cellular signaling pathways and abnormal growth. Herein, we give a brief overview of the basic genetic changes in cancer and discuss how specific gene alterations may contribute to the development of malignant melanoma.
| Translated title of the contribution | Acquired mutations--basic cancer biology |
|---|---|
| Original language | Danish |
| Journal | Ugeskrift for Laeger |
| Volume | 168 |
| Issue number | 24 |
| Pages (from-to) | 2335-8 |
| Number of pages | 4 |
| ISSN | 0041-5782 |
| Publication status | Published - 12 Jun 2006 |
| Externally published | Yes |