EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP

W J Fokkens; E De Corso; V Backer; M Bernal-Sprekelsen; L Bjermer; C von Buchwald; A Chaker; Z Diamant; P Gevaert; J Han; C Hopkins; V Hox; L Klimek; V J Lund; S Lee; A Luong; J Mullol; A Peters; O Pfaar; S Reitsma; S Toppila-Salmi; G K Scadding; A R Sedaghat; A-S Viskens; M Wagenmann; P W Hellings

doi:10.4193/Rhin23.415

EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP

W J Fokkens, E De Corso, V Backer, M Bernal-Sprekelsen, L Bjermer, C von Buchwald, A Chaker, Z Diamant, P Gevaert, J Han, C Hopkins, V Hox, L Klimek, V J Lund, S Lee, A Luong, J Mullol, A Peters, O Pfaar, S ReitsmaS Toppila-Salmi, G K Scadding, A R Sedaghat, A-S Viskens, M Wagenmann, P W Hellings

Department of Otorhinolaryngology, Head and Neck Surgery and Audiology

Abstract

Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP. In this paper a consensus on a list of definitions related to CRSwNP is provided: control, remission, cure, recurrence/exacerbation, treatable traits, remodeling, progression, and disease modification. By providing these definitions, the involved experts hope to improve communication between all stakeholders involved in CRSwNP treatment for use in routine care, basic and clinical research and international guidelines aimed to harmonize and optimize standard of care of patients with CRSwNP in the future.

Original language	English
Journal	Rhinology
Volume	62
Issue number	3
Pages (from-to)	287-298
Number of pages	12
ISSN	0300-0729
DOIs	https://doi.org/10.4193/Rhin23.415
Publication status	Published - 1 Jun 2024

Keywords

Chronic Disease
Humans
Nasal Polyps/therapy
Quality of Life
Rhinitis/therapy
Sinusitis/therapy

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Fokkens, W. J., De Corso, E., Backer, V., Bernal-Sprekelsen, M., Bjermer, L., von Buchwald, C., Chaker, A., Diamant, Z., Gevaert, P., Han, J., Hopkins, C., Hox, V., Klimek, L., Lund, V. J., Lee, S., Luong, A., Mullol, J., Peters, A., Pfaar, O., ... Hellings, P. W. (2024). EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP. Rhinology, 62(3), 287-298. https://doi.org/10.4193/Rhin23.415

Fokkens, WJ, De Corso, E, Backer, V, Bernal-Sprekelsen, M, Bjermer, L, von Buchwald, C, Chaker, A, Diamant, Z, Gevaert, P, Han, J, Hopkins, C, Hox, V, Klimek, L, Lund, VJ, Lee, S, Luong, A, Mullol, J, Peters, A, Pfaar, O, Reitsma, S, Toppila-Salmi, S, Scadding, GK, Sedaghat, AR, Viskens, A-S, Wagenmann, M & Hellings, PW 2024, 'EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP', Rhinology, vol. 62, no. 3, pp. 287-298. https://doi.org/10.4193/Rhin23.415

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abstract = "Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP. In this paper a consensus on a list of definitions related to CRSwNP is provided: control, remission, cure, recurrence/exacerbation, treatable traits, remodeling, progression, and disease modification. By providing these definitions, the involved experts hope to improve communication between all stakeholders involved in CRSwNP treatment for use in routine care, basic and clinical research and international guidelines aimed to harmonize and optimize standard of care of patients with CRSwNP in the future.",

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AU - von Buchwald, C

AU - Chaker, A

AU - Diamant, Z

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AU - Hox, V

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AU - Lund, V J

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AU - Pfaar, O

AU - Reitsma, S

AU - Toppila-Salmi, S

AU - Scadding, G K

AU - Sedaghat, A R

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N2 - Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP. In this paper a consensus on a list of definitions related to CRSwNP is provided: control, remission, cure, recurrence/exacerbation, treatable traits, remodeling, progression, and disease modification. By providing these definitions, the involved experts hope to improve communication between all stakeholders involved in CRSwNP treatment for use in routine care, basic and clinical research and international guidelines aimed to harmonize and optimize standard of care of patients with CRSwNP in the future.

AB - Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP. In this paper a consensus on a list of definitions related to CRSwNP is provided: control, remission, cure, recurrence/exacerbation, treatable traits, remodeling, progression, and disease modification. By providing these definitions, the involved experts hope to improve communication between all stakeholders involved in CRSwNP treatment for use in routine care, basic and clinical research and international guidelines aimed to harmonize and optimize standard of care of patients with CRSwNP in the future.

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EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP

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Keywords

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