Abstract
Patients with chronic kidney disease (CKD) have high cardiovascular mortality and morbidity associated with increased arterial stiffness. Plasma aldosterone levels are increased in CKD, and aldosterone has been found to increase vascular inflammation and fibrosis. It was hypothesized that aldosterone receptor inhibition with eplerenone could reduce arterial stiffness in CKD stage 3-4.
| Original language | English |
|---|---|
| Journal | P L o S One |
| Volume | 8 |
| Issue number | 5 |
| Pages (from-to) | e64549 |
| ISSN | 1932-6203 |
| DOIs | |
| Publication status | Published - 2013 |
Keywords
- Blood Pressure
- Demography
- Female
- Heart Rate
- Humans
- Male
- Middle Aged
- Mineralocorticoid Receptor Antagonists
- Pulse Wave Analysis
- Renal Insufficiency, Chronic
- Spironolactone
- Vascular Stiffness