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Epinephrine mediates facultative carbohydrate-induced thermogenesis in human skeletal muscle

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  1. Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue

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  2. Mechanisms of inhibition of vasopressin release during moderate antiorthostatic posture change in humans

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  3. Cardiovascular, endocrine, and renal effects of urodilatin in normal humans

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  4. Evaluation of the microdialysis technique in the dog fat pad

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  5. Fat metabolism in formerly obese women

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  1. Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP-1 but not GIP, CCK, and gastrin in plasma

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  2. The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years

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  3. Abdominal fat distribution measured by ultrasound and aerobic fitness in young Danish men born with low and normal birth weight

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The thermic effect of carbohydrate has a component mediated by the sympathoadrenal system but of unknown anatomical localization. We have studied the contribution of skeletal muscle to the thermic effect of a carbohydrate-rich natural meal (115 g of carbohydrate, approximately 80% of energy) by means of the forearm technique on two occasions, with and without intravenous beta-blockade with propranolol. The meal-induced thermogenesis was reduced from 9.6 to 7.1% by beta-blockade (P less than 0.04), the major difference was found 90 to 240 min after the meal. The postprandial increments in plasma glucose and lactate did not change by beta-blockade, but there was a trend toward a decreased insulin response (P = 0.06). The carbohydrate-induced increase in forearm oxygen consumption was reduced by 23% after beta-blockade (P less than 0.05), the entire difference being present 90-180 min postprandially and coinciding with the peak in arterial epinephrine. The present study provides evidence of a facultative thermogenic component in skeletal muscle, mediated by epinephrine via beta 2-adrenoreceptors. However, it also points to a nonmuscle component mediated through beta 1-adrenoceptors by norepinephrine released from the sympathetic nervous system. Consequently, the sympathoadrenal system seems to play a physiological role in the daily energy balance.
Original languageEnglish
JournalAmerican Journal of Physiology (Consolidated)
Volume257
Issue number3 Pt 1
Pages (from-to)E340-5
ISSN0002-9513
Publication statusPublished - Sep 1989

    Research areas

  • Adult, Body Temperature Regulation, Carbohydrates, Epinephrine, Female, Humans, Male, Muscles, Sympathetic Nervous System

ID: 39024014