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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Epigenetic therapy in hematological cancers

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  1. Bacteremia and urogenital infection with Actinomyces urogenitalis following prolonged urinary retention

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  4. Erythrocytes restrict microvesicle-induced production of reactive oxygen species by polymorphonuclear leukocytes

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  5. The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation

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  1. KMT2D mutations and TP53 disruptions are poor prognostic biomarkers in mantle cell lymphoma receiving high-dose therapy: a FIL study

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  2. Blodsygdomme

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The increasing depth of knowledge about cancer biology throughout the last decades, has underlined the importance of not only genetic aberrations, but also epigenetic abnormalities in cancer cells. The extensive exploration of the cancer epigenome has provided insights into key pathways involved in tumorigenesis, as well as has allowed the development of novel epigenetic therapies. In this review, we will present the important role of epigenetic alterations in hematological diseases, with special focus on epigenetically-based targeting of hematological malignancies.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume127
Issue number5
Pages (from-to)316-328
Number of pages13
ISSN0903-4641
DOIs
Publication statusPublished - 12 May 2019

    Research areas

  • DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors, DNA Methylation, Epigenesis, Genetic, Hematologic Neoplasms/drug therapy, Histone Deacetylase Inhibitors/therapeutic use, Histones/metabolism, Humans

ID: 57443452