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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Epigenetic therapy in hematological cancers

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  1. Mother-child transmission of epigenetic information by tunable polymorphic imprinting

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  2. Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies

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  3. Epidemiology of chronic red-cell transfusion recipients in Sweden and Denmark-a 10 year follow-up study

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The increasing depth of knowledge about cancer biology throughout the last decades, has underlined the importance of not only genetic aberrations, but also epigenetic abnormalities in cancer cells. The extensive exploration of the cancer epigenome has provided insights into key pathways involved in tumorigenesis, as well as has allowed the development of novel epigenetic therapies. In this review, we will present the important role of epigenetic alterations in hematological diseases, with special focus on epigenetically-based targeting of hematological malignancies.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume127
Issue number5
Pages (from-to)316-328
Number of pages13
ISSN0903-4641
DOIs
Publication statusPublished - 12 May 2019

    Research areas

  • DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors, DNA Methylation, Epigenesis, Genetic, Hematologic Neoplasms/drug therapy, Histone Deacetylase Inhibitors/therapeutic use, Histones/metabolism, Humans

ID: 57443452