Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age

Research output: Contribution to journalJournal articleResearchpeer-review

  1. International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Optimizing investigation of suspected allergy to polyethylene glycols

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Real-world evidence: Methods for assessing long-term health and effectiveness of allergy immunotherapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Chemicals in moisturizers may promote type 2 inflammation and food allergy

    Research output: Contribution to journalLetterResearchpeer-review

  5. Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council

    Research output: Contribution to journalReviewResearchpeer-review

  1. Allergic comorbidity is a risk factor for not attending scheduled outpatient visits in children with asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Long-term air pollution and road traffic noise exposure and COPD: the Danish Nurse Cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: The upper airways present a barrier to inhaled allergens and microbes, which alter immune responses and subsequent risk for diseases, such as allergic rhinitis (AR).

OBJECTIVE: We tested the hypothesis that early-life microbial exposures leave a lasting signature in DNA methylation that ultimately influences the development of AR in children.

METHODS: We studied upper airway microbiota at 1 week, 1 month, and 3 months of life, and measured DNA methylation and gene expression profiles in upper airway mucosal cells and assessed AR at age 6 years in children in the Copenhagen Prospective Studies on Asthma in Childhood birth cohort.

RESULTS: We identified 956 AR-associated differentially methylated CpGs in upper airway mucosal cells at age 6 years, 792 of which formed 3 modules of correlated differentially methylated CpGs. The eigenvector of 1 module was correlated with the expression of genes enriched for lysosome and bacterial invasion of epithelial cell pathways. Early-life microbial diversity was lower at 1 week (richness P = .0079) in children with AR at age 6 years, and reduced diversity at 1 week was also correlated with the same module's eigenvector (ρ = -0.25; P = 3.3 × 10-5). We show that the effect of microbiota richness at 1 week on risk for AR at age 6 years was mediated in part by the epigenetic signature of this module.

CONCLUSIONS: Our results suggest that upper airway microbial composition in infancy contributes to the development of AR during childhood, and this trajectory is mediated, at least in part, through altered DNA methylation patterns in upper airway mucosal cells.

Original languageEnglish
JournalThe Journal of allergy and clinical immunology
Volume146
Issue number6
Pages (from-to)1358-1366
Number of pages9
ISSN0091-6749
DOIs
Publication statusPublished - Dec 2020

Bibliographical note

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

ID: 61275083