Epidemic spread of Pandoraea apista, a new pathogen causing severe lung disease in cystic fibrosis patients

Inger Merete Jørgensen, Helle Krogh Johansen*, Birgitte Frederiksen, Tacjana Pressler, Annelise Hansen, Peter Vandamme, Niels Høiby, Christian Koch

*Corresponding author for this work


We show that Pandoraea apista must be added to the increasing list of pathogens capable of causing chronic lung infection in cystic fibrosis (CF) patients. It is most likely that this strain of P. apista was transmissible among patients with CF, leading to spread of infection from the index patient to 5 other patients exposed during participation in winter camps and/or hospitalization. All patients developed chronic infection with high levels of antibodies, and 4 patients had a downhill course of lung disease. P. apista must therefore be considered a new and sometimes important pathogen for CF patients. Cohort isolation prevented further spread of P. apista in our CF center.

Original languageEnglish
JournalPediatric Pulmonology
Issue number5
Pages (from-to)439-46
Number of pages8
Publication statusPublished - Nov 2003


  • Adult
  • Anti-Bacterial Agents/therapeutic use
  • Antibodies, Bacterial/blood
  • Bacterial Infections/blood
  • Betaproteobacteria/isolation & purification
  • Cohort Studies
  • Comorbidity
  • Cystic Fibrosis/epidemiology
  • Denmark/epidemiology
  • Disease Outbreaks
  • Disease Transmission, Infectious/statistics & numerical data
  • Drug Resistance, Bacterial
  • Female
  • Humans
  • Opportunistic Infections/blood
  • Respiratory Tract Infections/epidemiology
  • Sputum/microbiology
  • Treatment Outcome


Dive into the research topics of 'Epidemic spread of Pandoraea apista, a new pathogen causing severe lung disease in cystic fibrosis patients'. Together they form a unique fingerprint.

Cite this