Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Low versus High Carbohydrate Diet in Type 1 Diabetes: A 12-week randomized open-label crossover study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pleiotropic effects of liraglutide in patients with type 2 diabetes and moderate renal impairment: individual effects of treatment

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prevalence of heart failure and the diagnostic value of MR-proANP in outpatients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D vs. controls had increased EAT (4.6±1.8 mm vs. 3.4±1.2 mm, p<0.0001) and PAT (6.3±2.8 mm vs. 5.3±2.4 mm, p<0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all p<0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain (beta coefficient (SE)) (0.11% (0.04), p=0.002), while EAT was associated with reduced diastolic function by lateral e'(-0.31 (0.05) cm/s, p=0.001), E/A ratio (-0.02 (0.01), p=0.001), and lateral E/e' (0.36, (0.10), p<0.001). However, no interaction was found between diabetes status and PAT (p=0.75) or EAT (p=0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D vs. controls and associated with functional myocardial measures in T2D. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalDiabetes, Obesity and Metabolism
Volume21
Issue number8
Pages (from-to)2006-2011
Number of pages6
ISSN1462-8902
DOIs
Publication statusPublished - Aug 2019

Bibliographical note

© 2019 John Wiley & Sons Ltd.

    Research areas

  • cardiac adipose tissue, diastolic dysfunction, epicardial adipose tissue, pericardial adipose tissue, systolic dysfunction, type 2 diabetes

ID: 57192998