Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Environmental phenols and parabens in adipose tissue from hospitalized adults in Southern Spain

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults: The Danish Nurse cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Acetaminophen metabolism revisited using non-targeted analyses: Implications for human biomonitoring

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-term low-level ambient air pollution exposure and risk of lung cancer - A pooled analysis of 7 European cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Associations of serum phthalate metabolites with thyroid hormones in GraMo cohort, Southern Spain

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cohort profile: The COPENHAGEN Minipuberty Study-A longitudinal prospective cohort of healthy full-term infants and their parents

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Prenatal Exposure to Butyl Paraben Is Associated With Fat Percentage in 7-Year-Old Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Prenatal paraben exposure and anogenital distance and reproductive hormones during mini-puberty: A study from the Odense Child Cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  • F Artacho-Cordón
  • M F Fernández
  • H Frederiksen
  • L M Iribarne-Durán
  • I Jiménez-Díaz
  • F Vela-Soria
  • A M Andersson
  • P Martin-Olmedo
  • F M Peinado
  • N Olea
  • J P Arrebola
View graph of relations

Urinary concentrations of non-persistent environmental pollutants (npEPs) are widely assessed in biomonitoring studies under the assumption that they are metabolised and eliminated in urine. However, some of these chemicals are moderately lipophilic, and their presence in other biological matrices should also be evaluated to estimate mid/long-term exposure to npEPs and its impact on human health. The present study aims to explore concentrations and potential determinants of npEPs in adipose tissue from a hospital-based adult cohort (GraMo cohort, Southern Spain). Concentrations of bisphenol-A (BPA), benzophenone-3 (BP-3), triclosan (TCS), three chlorophenols (2,4-DCP, 2,5-DCP and 2,4,5-TCP) and two phenylphenols (2-PP and 4-PP), triclocarban (TCCB) and parabens [methyl- (MeP), ethyl- (EtP), propyl- (n-PrP and i-PrP), butyl- (n-BuP and i-BuP) and benzyl-paraben (BzP)] were analysed in adipose tissue samples from a subcohort of 144 participants. Spearman correlation tests were performed, followed by stepwise multivariable linear regression analyses to assess determinants of the exposure. Detection frequencies and median concentrations were: BPA (86.8%, 0.54 ng/g tissue), BP-3 (79.2%, 0.60 ng/g tissue), TCS (45.8%, <LOD), 2-PP (18.8%, <LOD), MeP (100.0%, 0.40 ng/g tissue), EtP (20.1%, <LOD) and n-PrP (54.2%, 0.06 ng/g tissue). The remaining npEPs were detected in <10% of the samples. BPA, MeP, EtP and n-PrP levels were significantly and positively correlated, while BP-3 showed a positive correlation with TCS and 2-PP. Older participants showed higher concentrations of TCS and MeP, while BMI was inversely associated with most of the analysed compounds and perceived recent weight loss was inversely associated with 2-PP. Female participants and residents of rural areas had increased BP-3 concentrations. npEP concentrations were positively associated with the consumption of fatty food but negatively associated with the consumption of vegetables and fruit. This study reveals the widespread presence of numerous npEPs in adipose tissue from adults in southern Spain, suggesting a generalized distribution of these environmental compounds in fatty tissues. In these adults, many of the determinants of npEP concentrations in adipose tissue were similar to those of more lipophilic and persistent compounds.

Original languageEnglish
JournalEnvironment International
Volume119
Pages (from-to)203-211
Number of pages9
ISSN0160-4120
DOIs
Publication statusPublished - Oct 2018

ID: 56304326