Enhanced uptake and photoactivation of topical methyl aminolevulinate after fractional CO2 laser pretreatment

M Haedersdal, J Katsnelson, F H Sakamoto, W A Farinelli, A G Doukas, J Tam, R R Anderson

99 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) of thick skin lesions is limited by topical drug uptake. Ablative fractional resurfacing (AFR) creates vertical channels that may facilitate topical PDT drug penetration and improve PDT-response in deep skin layers. The purpose of this study was to evaluate whether pre-treating the skin with AFR before topically applied methyl aminolevulinate (MAL) could enable a deep PDT-response.
Original languageEnglish
JournalLasers in Surgery and Medicine
Volume43
Issue number8
Pages (from-to)804-13
Number of pages10
ISSN0196-8092
DOIs
Publication statusPublished - 2011

Keywords

  • Administration, Topical
  • Aminolevulinic Acid
  • Animals
  • Combined Modality Therapy
  • Lasers, Gas
  • Male
  • Photochemotherapy
  • Photosensitizing Agents
  • Skin
  • Sus scrofa

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